Neuropathic pain presents a huge societal and individual burden. The limited efficacy of
current analgesics, diagnostic markers and clinical trial outcome measures arises from an …

Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Microglia play pivotal roles in controlling CNS functions in diverse physiological and
pathological contexts, including neuropathic pain, a chronic pain condition caused by …

Neuropathic pain is a serious consequence of injury or disease in the nervous system itself.
Current treatment options for this condition are often unsatisfactory. From being originally …

This special issue of Experimental Neurology is devoted to the role of Microglia and Chronic
Pain. Chronic pain affects 116 million people per year in the United States, which is more …

Neuropathic pain occurring after peripheral nerve injury is not simply a consequence of
temporal continuity of acute nociceptive signals, but rather of maladaptive nervous system …

Pain is a defense system that responds rapidly to harmful internal and external stimuli
through the somatosensory neuronal pathway. However, damage to the nervous system …

Microglial cells are specialized macrophage cells of the central nervous system responsible
for the innate immunity of the spinal cord and the brain. They protect the brain and spinal …

The microglia, once thought only to be supporting cells of the central nervous system (CNS),
are now recognized to play essential roles in many pathologies. Many studies within the last …

The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …