Importance After menopause, estradiol (E2) is predominately an intracrine hormone
circulating in very low serum concentrations. Objective The objective of this work is to …

Context: Accurate measurement of low serum estradiol (E2< 30 pg/ml or< 110 pmol/liter) is
needed to study relationships between endogenous E2 and risks of diseases in older …

Context There is a lack of understanding of what is normal in terms of sex steroid levels in
older women. Objective To determine whether sex steroid levels vary with age in and …

OBJECTIVE: To identify factors associated with serum estradiol (E2) levels among healthy
postmenopausal women using hormone therapy (HT). METHODS: This is an unplanned …

OBJECTIVES: To investigate the relationship between total estradiol (E2) levels and 9‐year
mortality in older postmenopausal women not taking hormone replacement therapy (HRT) …

Aims: We evaluated conjugated and unconjugated urinary estrogen metabolites as
surrogate biomarkers for serum levels of unconjugated E1 and E2 in premenopausal …

Background: Adverse effects of higher endogenous estradiol (E2) levels on various clinical
outcomes and on determinants of the frailty syndrome have recently been reported …

Purpose To report age-specific serum estradiol concentration in nonsmoking, lean US men
without comorbidities. We provide concentrations from 30 and 15 to 20 years ago given …

Context The lack of sensitive and robust analytical methods has hindered the reliable
quantification of estrogen metabolites in subjects with low concentrations. Objective To …

Background. Age trends in estradiol and estrone levels in men and how lifestyle factors,
comorbid conditions, testosterone, and sex hormone–binding globulin affect these age …