Nuclear protein in testis (NUT) carcinoma is a rare malignant neoplasm with an
undifferentiated morphology. Its diagnosis is often difficult, especially as the sinonasal tract …

Nuclear protein in testis (NUT) midline carcinoma (NMC) is a poorly differentiated squamous
cell carcinoma that is characterized by a balanced translocation between chromosomes 15 …

Discussion NUT carcinoma is an aggressive and invariably fatal carcinoma that generally
affects young adults. 1 As a clinicopathologic entity, it has, to our knowledge, only been …

Background Bromodomain and extra-terminal domain proteins are promising epigenetic
anticancer drug targets. This first-in-human study evaluated the safety, recommended phase …

Background BET inhibitors have been tested in several clinical trials where, despite
encouraging preclinical results, substantial clinical benefit in monotherapy remains limited …

NUT midline carcinoma (NMC) is a rare and aggressive disease encountered in the midline
of the head and neck or mediastinum. Due to its sparse incidence and subtle pathologic …

Bromodomain and extraterminal domain (BET) proteins are epigenetic readers that regulate
gene expression and are involved in cancer pathogenesis. Over the last years, several BET …

OBJECTIVE. NUT midline carcinoma is a rare poorly differentiated aggressive subtype of
squamous cell carcinoma. To date, fewer than 100 total cases have been reported …

NUT carcinoma (NC) is an extremely aggressive squamous cancer with no effective therapy.
NC is driven, most commonly, by the BRD4-NUT fusion oncoprotein. BRD4-NUT combines …

In this study, we report 2 pediatric cases of nuclear protein of the testis (NUT) midline
carcinoma (NMC) suggestive of pulmonary origin: case 1 was a 14-year-old Japanese boy …