Although some advances have been made in the treatment of osteosarcoma in recent years,
surgical resection remains the mainstream treatment. Initial and early diagnosis of …

The identification of new therapeutic targets and the development of innovative therapeutic
approaches are the most important challenges for osteosarcoma treatment. In fact, despite …

The importance of ubiquitin and ubiquitin-like proteins in physiology and medicine has
evolved tremendously during the past 2 decades largely due to the exponential …

Cancer metastasis refers to the dissemination of primary cancer cells into secondary organs.
Metastasis is the primary cause of cancer-associated deaths worldwide and remains the …

In children and young adults, primary malignant bone tumours are mainly composed of
osteosarcoma and Ewing's sarcoma. Despite advances in treatments, nearly 40% of patients …

Ubiquitination is an important post-translational modification. Abnormal ubiquitination is
extensively associated with cancers. Lung squamous cell carcinoma (LUSC) is the most …

Background Osteosarcoma is the most common bone tumor that occurs in children. Methods
To identify co-expression modules and pathways correlated with osteosarcoma and its …

Background The cancer occurrence and progression are largely affected by the post-
translational modifications (PTMs) of proteins. Currently, it has been shown that the …

The ubiquitin–proteasome system is an important pathway for mediating posttranslational
modification and protein homeostasis and exerts a wide range of functions in diverse …

Dynamic modulation and posttranslational modification of proteins are tightly controlled
biological processes that occur in response to physiological cues. One such dynamic …