The density and type of lymphocytes that infiltrate colon tumors are predictive of the clinical
outcome of colon cancer. High densities of TH17 cells and inflammation predict poor …

The density and type of lymphocytes that infiltrate colon tumors are predictive of the clinical
outcome of colon cancer. High densities of T helper 17 (TH17) cells and inflammation …

Chronic inflammation drives colitis-associated colorectal cancer (CAC) in inflammatory
bowel disease (IBD). FoxP3+ regulatory T cells (Treg) coexpressing the Th17-related …

The diversity of regulatory T (Treg) cells in health and in disease remains unclear.
Individuals with colorectal cancer harbor a subpopulation of RORγt+ Treg cells with elevated …

In the colonic environment, sustained Wnt–β-catenin activation in regulatory T cells
promotes epigenetic rewiring toward proinflammatory RORγt+ Treg cells, whose expansion …

The role of regulatory T cells (Tregs) in human colon cancer (CC) remains controversial:
high densities of tumor-infiltrating Tregs can correlate with better or worse clinical outcomes …

RORγt+ group 3 innate lymphoid cells (ILC3s) are essential for intestinal homeostasis.
Dysregulation of ILC3s has been found in the gut of patients with inflammatory bowel …

The tumor microenvironment includes a complex network of immune T-cell subpopulations.
In this study, we systematically analyzed the balance between cytotoxic T cells and different …

The transcription factor TCF-1 is essential for the development and function of regulatory T
(Treg) cells; however, its function is poorly understood. Here, we show that TCF-1 primarily …

Understanding how colorectal cancer escapes from immunosurveillance and immune attack
is important for developing novel immunotherapies for colorectal cancer. In this study we …