P-Glycoprotein (PGP) encoded by the multi-drug-resistance 1 (MDR1) gene is a member of
theATP-binding cassette (ABC) transporter family, drug-transporting proteins involved in the …

Abstract C1236T, G2677T/A, and C3435T polymorphism of the multidrug resistance (MDR1)
gene have substantial impact on expression or activity of P‐glycoprotein (P‐gp). We …

The human multidrug resistance gene (MDR1), spanning greater than 200 kb, encodes for
the ATP-dependent membrane efflux transporter, P-glycoprotein (Pgp). Significant progress …

The objective of this study was to develop a real-time polymerase chain reaction (PCR)
method to detect MDR1 (human multidrug resistance gene) single nucleotide …

The multidrug resistance (MDR1) gene product P-glycoprotein is a membrane protein that
functions as an ATP-dependent efflux pump, transporting exogenous and endogenous …

In vivo and in vitro studies have demonstrated that P-glycoprotein (P-gp) plays a very
significant role in the ADME processes (absorption, distribution, metabolism, excretion) and …

Abstract P-glycoprotein (PGP), the product of the multidrug resistance gene (MDR1), acts as
an energy-dependent efflux pump that exports its substrates out of the cell. PGP expression …

Summary P-glycoprotein (P-gp) is an ATP-dependent efflux pump which has great
importance in absorption and elimination of several important drugs. The MDR1 (Multiple …

The two most frequently observed single nucleotide polymorphisms (SNPs) of the human
multidrug resistance 1 (MDR1) gene are 2677G/T/A (893Ala/Ser/Thr) and 3435C/T (no …

Background P‐glycoprotein, the gene product of MDR1, confers multidrug resistance
against antineoplastic agents but also plays an important role in the bioavailability of …