Major histocompatibility complex class I (MHC I) molecules are glycoproteins that display
peptide epitopes at the cell surface of nucleated cells for recognition by CD8+ T cells. Like …

Cross-presentation, in which exogenous antigens are presented via MHC I complexes, is
involved both in the generation of anti-infectious and anti-tumoral cytotoxic CD8+ T cells and …

Background Cross-presentation by dendritic cells (DCs) is a crucial prerequisite for effective
priming of cytotoxic T-cell responses against bacterial, viral and tumor antigens; however …

Highlights•Dendritic cells internalize exogenous antigens for cross-presentation on MHC
I.•MHC I cross-presentation allows immune surveillance of viral infection and …

Cross‐presentation of internalized antigens by dendritic cells requires efficient delivery of
Major Histocompatibility Complex (MHC) class I molecules to peptide‐loading …

Antigenic peptide-loaded MHC class II molecules (peptide–MHC class II) are constitutively
expressed on the surface of professional antigen-presenting cells (APCs), including …

MHC class II molecules (MHC-II) present antigenic fragments acquired in the endocytic route
to the immune system for recognition and activation of CD4+ T cells. This ignites a series of …

How are extracellular proteins cross-presented on MHC class I molecules? In this issue of
Immunity, Ackerman et al.(2006) demonstrate that the ER-associated degradation (ERAD) …

Summary MHC class I (MHC‐I) molecules are the centerpieces of cross‐presentation. They
are loaded with peptides derived from exogenous sources and displayed on the plasma …

Peptides presented by MHC class I molecules are mostly derived from proteins synthesized
by the antigen‐presenting cell itself, while peptides presented by MHC class II molecules …