Pain is the most common sensation installed in us naturally which plays a vital role in
defending us against severe harm. This neurological mechanism pathway has been one of …

Pain has been considered as a concept of sensation that we feel as a reaction to the
stimulus of our surrounding, putting us in harm's way and acting as a form of defense …

Pain is an unpleasant sensation, which informs about any abnormality in either body or part
of it. Pain may be either physical or mental depending on its source of origin. Generally …

Human experimental pain models are essential in understanding the pain mechanisms and
appear to be ideally suited to test analgesic compounds. The challenge that confronts both …

Pain is a complex multidimensional concept that facilitates the initiation of the signaling
cascade in response to any noxious stimuli. Action potential generation in the peripheral …

Neuropathic pain is maladaptive pain caused by injury or dysfunction in peripheral and
central nervous system, and remains a worldwide thorny problem leading to decreases in …

The current gap between basic science research and the development of new analgesics
presents a serious challenge for the future of pain medicine. This challenge is particularly …

Globally, over 300 million surgical procedures are performed annually, with pain being one
of the most common post-operative side effects. During the onset of injury, acute pain plays …

Despite the myriad promising new targets and candidate analgesics recently identified in
preclinical pain studies, little translation to novel pain medications has been generated. The …

Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …