Tacrolimus in the treatment of childhood nephrotic syndrome: Machine learning detects novel biomarkers and predicts efficacy
X Mo, X Chen, H Zeng, W Zheng… - … : The Journal of …, 2023 - Wiley Online Library
Abstract Study Objective The pharmacokinetics and pharmacodynamics of tacrolimus (TAC)
vary greatly among individuals, hindering its precise utilization. Moreover, effective models …
vary greatly among individuals, hindering its precise utilization. Moreover, effective models …
Tacrolimus pharmacokinetics in pediatric nephrotic syndrome: A combination of population pharmacokinetic modelling and machine learning approaches to improve …
Q Huang, X Lin, Y Wang, X Chen, W Zheng… - Frontiers in …, 2022 - frontiersin.org
Background and Aim: Tacrolimus (TAC) is a first-line immunosuppressant for the treatment
of refractory nephrotic syndrome (RNS), but the pharmacokinetics of TAC varies widely …
of refractory nephrotic syndrome (RNS), but the pharmacokinetics of TAC varies widely …
Prediction of tacrolimus dose/weight-adjusted trough concentration in pediatric refractory nephrotic syndrome: A machine learning approach
X Mo, X Chen, X Wang, X Zhong, H Liang… - Pharmacogenomics …, 2022 - Taylor & Francis
Purpose Tacrolimus (TAC) is a first-line immunosuppressant for patients with refractory
nephrotic syndrome (NS). However, there is a high inter-patient variability of TAC …
nephrotic syndrome (NS). However, there is a high inter-patient variability of TAC …
[HTML][HTML] Early prediction of tacrolimus-induced tubular toxicity in pediatric refractory nephrotic syndrome using machine learning
X Mo, X Chen, C Ieong, X Gao, Y Li, X Liao… - Frontiers in …, 2021 - frontiersin.org
Background and Aims: Tacrolimus (TAC)-induced nephrotoxicity, which has a large
individual variation, may lead to treatment failure or even the end-stage renal disease …
individual variation, may lead to treatment failure or even the end-stage renal disease …
Dose tailoring of tacrolimus based on a non-linear pharmacokinetic model in children with refractory nephrotic syndrome
L Li, M Zhu, DY Li, HL Guo, YH Hu, ZY Xu… - International …, 2021 - Elsevier
The population pharmacokinetics (PPK) of tacrolimus (TAC) in children with refractory
nephrotic syndrome (RNS) have not been well-characterized. This study aimed to …
nephrotic syndrome (RNS) have not been well-characterized. This study aimed to …
Population pharmacokinetic study of tacrolimus in pediatric patients with primary nephrotic syndrome: A comparison of linear and nonlinear Michaelis–Menten …
L Huang, Y Liu, Z Jiao, J Wang, L Fang… - European Journal of …, 2020 - Elsevier
Background Little is known about the population pharmacokinetics (PPK) of tacrolimus
(TAC) in pediatric patients with primary nephrotic syndrome (PNS). In this study, we aimed to …
(TAC) in pediatric patients with primary nephrotic syndrome (PNS). In this study, we aimed to …
Population pharmacokinetics and dosage optimization of tacrolimus in pediatric patients with nephrotic syndrome
X Wang, Y Han, C Chen, L Ma, H Xiao… - … Journal of Clinical …, 2019 - search.proquest.com
Objectives: The aims of this study were to investigate the population pharmacokinetic (PPK)
characteristics of tacrolimus in Chinese children with nephrotic syndrome and to apply it in …
characteristics of tacrolimus in Chinese children with nephrotic syndrome and to apply it in …
Tacrolimus treatment in childhood refractory nephrotic syndrome: a retrospective study on efficacy, therapeutic drug monitoring, and contributing factors to variable …
HL Guo, J Xu, JY Sun, L Li, HL Guo, X Jing… - International …, 2020 - Elsevier
Tacrolimus, an immunosuppressive drug, was recommended by the 2012 KDIGO guidelines
to treat nephrotic syndrome (NS) in children and adults. However, it has high interpatient …
to treat nephrotic syndrome (NS) in children and adults. However, it has high interpatient …
Population pharmacokinetic evaluation with external validation of tacrolimus in Chinese primary nephrotic syndrome patients
L Yang, N Yang, B Yi, Q Pei, Z Huang - Pharmaceutical Research, 2022 - Springer
Purpose The generalizability of numerous tacrolimus population pharmacokinetic (popPK)
models constructed to promote optimal tacrolimus dosing in patients with primary nephrotic …
models constructed to promote optimal tacrolimus dosing in patients with primary nephrotic …
Population pharmacokinetic study of tacrolimus in pediatric patients with primary nephrotic syndrome
L HUANG, C ZHAO, Z JIAO, Y LIU… - Acta Pharmaceutica …, 2018 - pesquisa.bvsalud.org
Tacrolimus is commonly used in the treatment for the refractory primary nephrotic syndrome
(PNS) in the pediatric patients. Data were retrospectively obtained from 100 children with …
(PNS) in the pediatric patients. Data were retrospectively obtained from 100 children with …