Low‐dose ketamine affects blood pressure, but not muscle sympathetic nerve activity, during progressive central hypovolemia without altering tolerance
Key points Haemorrhage is the leading cause of battlefield and civilian trauma deaths.
Given that a haemorrhagic injury on the battlefield is almost always associated with pain, it is …
Given that a haemorrhagic injury on the battlefield is almost always associated with pain, it is …
Comparing the effects of low-dose ketamine, fentanyl, and morphine on hemorrhagic tolerance and analgesia in humans
Hemorrhage is a leading cause of preventable battlefield and civilian trauma deaths.
Ketamine, fentanyl, and morphine are recommended analgesics for use in the prehospital …
Ketamine, fentanyl, and morphine are recommended analgesics for use in the prehospital …
Low dose ketamine reduces pain perception and blood pressure, but not muscle sympathetic nerve activity, responses during a cold pressor test
Key points Low dose ketamine is a leading medication used to provide analgesia in pre‐
hospital and hospital settings. Low dose ketamine is increasingly used off‐label to treat …
hospital and hospital settings. Low dose ketamine is increasingly used off‐label to treat …
Fentanyl impairs but ketamine preserves the microcirculatory response to hemorrhage
L Xiang, AS Calderon, HG Klemcke… - Journal of Trauma …, 2020 - journals.lww.com
BACKGROUND Peripheral vasoconstriction is the most critical compensating mechanism
following hemorrhage to maintain blood pressure. On the battlefield, ketamine rather than …
following hemorrhage to maintain blood pressure. On the battlefield, ketamine rather than …
Effects of ketamine analgesia on cardiorespiratory responses and survival to trauma and hemorrhage in rats
HG Klemcke, ML Calderon… - Journal of Applied …, 2021 - journals.physiology.org
Ketamine is the recommended analgesic on the battlefield for soldiers with hemorrhage,
despite a lack of supportive evidence from laboratory or clinical studies. Hence, this study …
despite a lack of supportive evidence from laboratory or clinical studies. Hence, this study …
Racemic ketamine decreases muscle sympathetic activity but maintains the neural response to hypotensive challenges in humans
P Kienbaum, T Heuter, MC Michel… - The Journal of the …, 2000 - pubs.asahq.org
Background Cardiovascular stimulation and increased catecholamine plasma
concentrations during ketamine anesthesia have been attributed to increased central …
concentrations during ketamine anesthesia have been attributed to increased central …
Low-dose fentanyl does not alter muscle sympathetic nerve activity, blood pressure, or tolerance during progressive central hypovolemia
Hemorrhage is a leading cause of battlefield and civilian trauma deaths. Several pain
medications, including fentanyl, are recommended for use in the prehospital (ie, field setting) …
medications, including fentanyl, are recommended for use in the prehospital (ie, field setting) …
Sympathetic nervous system sensitivity to hemorrhagic hypotension in the subhuman primate
B CHERNOW, CR LAKE, M BARTON… - Journal of Trauma …, 1984 - journals.lww.com
The endogenous catecholamine response to hemorrhagic hypotension is poorly defined
since most data have been derived from experiments in lower animal species. To clarify this …
since most data have been derived from experiments in lower animal species. To clarify this …
S (+)-Ketamine Increases Muscle Sympathetic Activity and Maintains the Neural Response to Hypotensive Challenges in Humans
P Kienbaum, T Heuter, G Pavlakovic… - The Journal of the …, 2001 - pubs.asahq.org
Background S (+)-Ketamine is reported to exert twofold greater analgesic and hypnotic
effects but a shorter recovery time in comparison with racemic ketamine, indicating possible …
effects but a shorter recovery time in comparison with racemic ketamine, indicating possible …
Low-dose morphine reduces tolerance to central hypovolemia in healthy adults without affecting muscle sympathetic outflow
Hemorrhage is a leading cause of preventable battlefield and civilian trauma deaths. Low-
dose (ie, an analgesic dose) morphine is recommended for use in the prehospital (ie, field) …
dose (ie, an analgesic dose) morphine is recommended for use in the prehospital (ie, field) …