Schwann cells (SCs) have a critical role in the peripheral nervous system. These cells are
able to support axons during homeostasis and after injury. However, mutations in genes …

Peripheral nerve injuries arising from trauma or disease can lead to sensory and motor
deficits and neuropathic pain. Despite the purported ability of the peripheral nerve to self …

How tissues are maintained over a lifetime and repaired following injury are fundamental
questions in biology with a disruption to these processes underlying pathologies such as …

Mesenchymal stem cells (MSCs) have considerable translational potential in a wide variety
of clinical disciplines and are the cellular foundation of individualized treatments of auto …

The remarkable feature of Schwann cells (SCs) to transform into a repair phenotype turned
the spotlight on this powerful cell type. SCs provide the regenerative environment for axonal …

Repair in the peripheral nervous system (PNS) depends upon the plasticity of the
myelinating cells, Schwann cells, and their ability to dedifferentiate, direct axonal regrowth …

Abstract Since Schwann cells (SCs) support axonal growth at development as well as after
peripheral nerve injury (PNI), developing SCs might be able to promote axon regeneration …

Peripheral nerves exist in a stable state in adulthood providing a rapid bidirectional
signaling system to control tissue structure and function. However, following injury …

Despite a substantially increased understanding of neuropathophysiology, insufficient
functional recovery after peripheral nerve injury remains a significant clinical challenge …

The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …