Following peripheral nerve injury, successful axonal growth and functional recovery require
Schwann cell (SC) reprogramming into a reparative phenotype, a process dependent upon …

The interaction between neurons and glial cells is a feature of all higher nervous systems. In
the vertebrate peripheral nervous system, Schwann cells ensheath and myelinate axons …

Outcomes following peripheral nerve injury remain frustratingly poor. The reasons for this
are multifactorial, although maintaining a growth permissive environment in the distal nerve …

After peripheral nerve injury, mature Schwann cells (SCs) de‐differentiate and undergo cell
reprogramming to convert into a specialized cell repair phenotype that promotes nerve …

The fundamental roles of Schwann cells during peripheral nerve formation and regeneration
have been recognized for more than 100 years, but the cellular and molecular mechanisms …

Abstract Transplantation of Schwann cells (SCs) has been extensively investigated as a
therapeutic intervention in rodent models of spinal cord injury (SCI). Here we review both …

Active neuroscientists survey NSCs as potential tools for central nervous system and spinal
cord repair by explaining their clinically significant fundamental properties, manipulations …

Repair of the central nervous system (CNS) constitutes an integral part of treating
neurological disease and plays a crucial role in restoring CNS architecture and function …

This study comprehensively addresses the phenotype, function, and whole transcriptome of
primary human and rodent Schwann cells (SCs) and highlights key species-specific features …

Schwann cells (SCs) are fundamental components of the peripheral nervous system (PNS)
of all vertebrates and play essential roles in development, maintenance, function, and …