Acute noise-induced loss of synapses between inner hair cells (IHCs) and auditory nerve
fibers (ANFs) has been documented in several strains of mice, but the extent of post …

Cochlear synaptopathy is the noise-induced or age-related loss of ribbon synapses between
inner hair cells (IHCs) and auditory-nerve fibers (ANFs), first reported in CBA/CaJ mice …

In CBA/CaJ mice, confocal analysis has shown that acoustic overexposure can immediately
destroy synapses between auditory-nerve fibers (ANFs) and their peripheral targets, the …

Overexposure to intense noise can destroy the synapses between auditory nerve fibers and
their hair cell targets without destroying the hair cells themselves. In adult mice, this …

Noise exposure of a short period at a moderate level can produce permanent cochlear
synaptopathy without seeing lasting changes in audiometric threshold. However, due to the …

Acoustic overexposure can eliminate synapses between inner hair cells (IHCs) and auditory
nerve fibers (ANFs), even if hair-cell function recovers. This synaptopathy has been …

Recent studies on animal models have shown that noise exposure that does not lead to
permanent threshold shift (PTS) can cause considerable damage around the synapses …

Animal studies suggest that cochlear nerve degeneration precedes sensory cell
degeneration in both noise-induced hearing loss (NIHL) and age-related hearing loss …

It is widely accepted that even a single acute noise exposure at moderate intensity that
induces temporary threshold shift (TTS) can result in permanent loss of ribbon synapses …

Prior work has provided extensive documentation of threshold sensitivity and sensory hair
cell losses after noise exposure. It is now clear, however, that cochlear synaptic loss …