There is a dynamic relationship between physical and biochemical signals presented in the
stem cell microenvironment to guide cell fate determination. Model systems that modulate …

Cell patterning is typically accomplished by selectively depositing proteins for cell adhesion
only on patterned regions; however in tissues, cells are also influenced by mechanical …

Dimensionality can have a profound impact on stiffness-mediated differentiation of
mesenchymal stem cells (MSCs). However, while we have begun to understand cellular …

Adult stem cells hold great promise as a source of diverse terminally differentiated cell types
for tissue engineering applications. However, due to the complexity of chemical and …

Stem cells reside in a multi-factorial environment containing biochemical and mechanical
signals. Changing biochemical signals in most scaffolds often leads to simultaneous …

Biomaterial designs are increasingly incorporating multiple instructive signals to induce a
desired cell response. However, many approaches do not allow orthogonal manipulation of …

The ability of stem cells to differentiate into specified lineages in the appropriate locations is
vital to morphogenesis and adult tissue regeneration. Although soluble signals are important …

Out of their niche environment, adult stem cells, such as mesenchymal stem cells (MSCs),
spontaneously differentiate. This makes both studying these important regenerative cells …

Cells sense and transduce the chemical and mechanical properties of their
microenvironment through cell surface integrin receptors. Traction stress exerted by cells on …

The physical properties of the extracellular matrix (ECM) play an important role in regulating
tissue-specific human mesenchymal stem cell (MSC) differentiation. Protein-coated …