Purpose Epigenetic modification including of DNA methylation, histone acetylation, histone
methylation, histon phosphorylation and non-coding RNA can impress the gene expression …

Gastric cancer is the second most prevalent cause of cancer death worldwide. DNA
methylation is a common event in gastric carcinogenesis. hTERT seems to be the rate …

Purpose Telomerase activity is associated with cellular immortalization and is present in
most human tumors but absent in normal tissues. The activity of telomerase reverse …

Although hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide, the
molecular pathogenesis of the disease has not been elucidated. Several studies have …

BACKGROUND AND AIMS: Telomerase is expressed in normal somatic cells and
reactivated in majority of tumor cells. Human telomerase reverse transcriptase (hTERT), a …

Abstract Background and Aims: Telomerase activity is thought to be necessary for cellular
immortality and carcinogenesis. The mRNA that encodes the telomerase catalytic subunit …

AIM: To investigate the expression of human telomerase reverse transcriptase gene (hTRT)
in gastric cancer (GC) and its relevance with cell cycle regulators including P16INK4, cyclin …

Genetic instabilities exacerbated by the dysfunction of telomeres can lead to the
development of cancer. Nearly 90% of all human malignancies are linked with telomere …

AIM: To investigate telomerase activity and hTERT, TP-1 expression and their relationships
in esophageal squamous cell carcinoma (ESCC). METHODS: Telomerase activity was …

The extent to which human telomerase reverse transcriptase (hTERT) mRNA and its splice
variants control telomerase activity in human cancers is controversial. Telomerase and …