Background and purpose: Tissue deposits of the anti‐arrhythmic drug amiodarone are a
major source of side effects (skin discoloration, etc.). We addressed the mechanism of the …

Amiodarone is widely used to treat cardiac arrhythmias and is very effective in preventing
these disorders. However, its use is limited by a wide range of adverse effects, mainly …

Amiodarone is a unique class III antiarrhythmic drug with several unusual pharmacokinetic,
pharmacodynamic, and toxicological actions which are quite distinct from those of the …

Amiodarone is a cationic amphiphilic drug used as an antiarrhythmic agent. It induces
phospholipidosis, ie, the accumulation of phospholipids within organelles of the endosomal …

Amiodarone, bi-iodinated benzofuran derivative, is one of the most frequently prescribed
and efficacious antiarrhythmic drugs. Despite its low incidence, amiodarone-induced …

Patients treated with amiodarone accumulate lysobisphosphatidic acid (LBPA), also known
as bis (monoacylglycero) phosphate, in airway secretions and develop in different tissues …

Amiodarone-induced pulmonary toxicity is a serious side-effect, but the underlying
molecular mechanisms remain unclear. We examined phospholipidosis and apoptosis in rat …

Cardiac and extra-cardiac side effects of common antiarrhythmic agents might be related to
drug-induced mitochondrial dysfunction. Supratherapeutic doses of amiodarone have been …

Amiodarone is a widely used antiarrhythmic drug that can cause the development of
steatohepatitis as well as liver fibrosis and cirrhosis. The molecular mechanisms of …

The antiarrhythmic agent amiodarone, a cationic amphiphilic drug, is known to induce
phospholipidosis, ie the accumulation of phospholipids within lysosomal structures to give …