[图书][B] Use of Lab-Evolved Proteins to Guide Development of Inhibitors that Target HIV-1 TAR RNA
SS Chavali - 2021 - search.proquest.com
Non-coding (nc) RNAs demonstrate structural versatility to regulate genes at multiple levels.
Many RNAs bind a variety of protein motifs to perform gene-regulatory activities at the …
Many RNAs bind a variety of protein motifs to perform gene-regulatory activities at the …
Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors
RNA-protein interfaces control key replication events during the HIV-1 life cycle. The viral
trans-activator of transcription (Tat) protein uses an archetypal arginine-rich motif (ARM) to …
trans-activator of transcription (Tat) protein uses an archetypal arginine-rich motif (ARM) to …
Structural mimicry of retroviral tat proteins by constrained β-hairpin peptidomimetics: ligands with high affinity and selectivity for viral TAR RNA regulatory elements
Z Athanassiou, RLA Dias, K Moehle… - Journal of the …, 2004 - ACS Publications
An approach is described to the design of β-hairpin peptidomimetic ligands for bovine
immunodeficiency virus (BIV) Tat protein, which inhibit binding to its transactivator response …
immunodeficiency virus (BIV) Tat protein, which inhibit binding to its transactivator response …
TAR RNA Recognition by a Cyclic Peptidomimetic of Tat Protein,
The search for new antiviral drugs that repress HIV viral replication by blocking
transactivation of viral RNA transcription has long been advocated as an approach to novel …
transactivation of viral RNA transcription has long been advocated as an approach to novel …
Essential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat protein
A Davidson, K Patora-Komisarska… - Nucleic acids …, 2011 - academic.oup.com
The pharmacological disruption of the interaction between the HIV Tat protein and its
cognate transactivation response RNA (TAR) would generate novel anti-viral drugs with a …
cognate transactivation response RNA (TAR) would generate novel anti-viral drugs with a …
An evolved RNA recognition motif that suppresses HIV-1 Tat/TAR-dependent transcription
DW Crawford, BD Blakeley, PH Chen… - ACS chemical …, 2016 - ACS Publications
Potent and selective recognition and modulation of disease-relevant RNAs remain a
daunting challenge. We previously examined the utility of the U1A N-terminal RNA …
daunting challenge. We previously examined the utility of the U1A N-terminal RNA …
Inhibitors of protein− RNA complexation that target the RNA: specific recognition of human immunodeficiency virus type 1 TAR RNA by small organic molecules
HY Mei, M Cui, A Heldsinger, SM Lemrow, JA Loo… - Biochemistry, 1998 - ACS Publications
TAR RNA represents an attractive target for the intervention of human immunodeficiency
virus type 1 (HIV-1) replication by small molecules. We now describe three small molecule …
virus type 1 (HIV-1) replication by small molecules. We now describe three small molecule …
Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein
A Davidson, TC Leeper… - Proceedings of the …, 2009 - National Acad Sciences
The interaction of the HIV-1 transactivator protein Tat with its transactivation response (TAR)
RNA is an essential step in viral replication and therefore an attractive target for developing …
RNA is an essential step in viral replication and therefore an attractive target for developing …
Inhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNA
MS Lalonde, MA Lobritz, A Ratcliff… - PLoS …, 2011 - journals.plos.org
The RNA response element TAR plays a critical role in HIV replication by providing a
binding site for the recruitment of the viral transactivator protein Tat. Using a structure-guided …
binding site for the recruitment of the viral transactivator protein Tat. Using a structure-guided …
Recent advances in targeting the HIV-1 Tat/TAR complex
FA Abulwerdi, SFJ Le Grice - Current pharmaceutical design, 2017 - ingentaconnect.com
Following seminal discoveries by Rosen and co-workers in 1985, the HIV-1 TAR has
emerged as one of the most extensively studied regulatory elements of the HIV-1 genome …
emerged as one of the most extensively studied regulatory elements of the HIV-1 genome …