The HIV-1 trans-activator protein Tat binds the trans-activation response element (TAR) to
facilitate recruitment of the super elongation complex (SEC) to enhance transcription of the …

Abstract The HIV-2 TAR RNA domain (TAR-2) plays a key role in the trans-activation of HIV-
2 transcription as it is the target for the Tat-2 protein and several cell factors. Here, we show …

Natural and lab-evolved proteins often recognize their RNA partners with exquisite affinity.
Structural analysis of such complexes can offer valuable insight into sequence-selective …

Replication of human immunodeficiency virus type 1 (HIV-1) requires specific interactions of
Tat protein with the trans-activation responsive region (TAR) RNA, a 59-base stem-loop …

Small molecules and short peptides that potently and selectively bind RNA are rare, making
the molecular structures of these complexes highly exceptional. Accordingly, several recent …

Efforts toward the development of RNA-based drug leads have been challenging because of
the complexity and dynamic nature of RNA structures as therapeutic targets. The …

Small molecules that bind to RNA potently and specifically are relatively rare. The study of
molecules that bind to the HIV-1 transactivation response (TAR) hairpin, a cis-acting HIV …

Sir-The Tat protein of human immunodeficiency virus type-I (HIV-1) binds to its target RNA,
TAR, and activates transcription. A 36 amino acid peptide, Tat (37-72), containing RNA …

The human immunodeficiency virus type‐1 (HIV‐1) Tat protein stimulates transcriptional
elongation. Tat is involved in the transcription machinery by binding to the transactivation …