Targeting the HIV Trans‐Activation Responsive Region—Approaches Towards RNA‐Binding Drugs
A Krebs, V Ludwig, O Boden, MW Göbel - ChemBioChem, 2003 - Wiley Online Library
RNA±protein interactions are essential for many biological processes such as translation,
RNA splicing, and transcription. For a long time, RNA was regarded mainly as a passive …
RNA splicing, and transcription. For a long time, RNA was regarded mainly as a passive …
Structure-based drug design targeting an inactive RNA conformation: exploiting the flexibility of HIV-1 TAR RNA
AIH Murchie, B Davis, C Isel, M Afshar… - Journal of molecular …, 2004 - Elsevier
The targeting of RNA for the design of novel anti-viral compounds represents an area of vast
potential. We have used NMR and computational methods to model the interaction of a …
potential. We have used NMR and computational methods to model the interaction of a …
200 Potent inhibition of HIV replication by RNA-binding peptide mimetics with unprecedented specificity
G Varani - Journal of Biomolecular Structure and Dynamics, 2013 - Taylor & Francis
RNA provides an inviting target for pharmaceutical intervention in both infectious and
chronic diseases, but it has so far been impossible to identify drug-like molecules with …
chronic diseases, but it has so far been impossible to identify drug-like molecules with …
Novel HIV-1 Transcription Inhibitors Targeting TAR RNA
A Alanazi - 2020 - search.proquest.com
Current approved antiretroviral medications used to treat HIV-1 infection have targeted
different steps in HIV-1 life cycle including, entry, fusion, integration, reverse transcription …
different steps in HIV-1 life cycle including, entry, fusion, integration, reverse transcription …
Conserved nucleotides in the TAR RNA stem of human immunodeficiency virus type 1 are critical for Tat binding and trans activation: model for TAR RNA tertiary …
U Delling, LS Reid, RW Barnett, MY Ma… - Journal of …, 1992 - Am Soc Microbiol
Interaction between the human immunodeficiency virus type 1 (HIV-1) trans-activator Tat
and its cis-acting responsive RNA element TAR is necessary for activation of HIV-1 gene …
and its cis-acting responsive RNA element TAR is necessary for activation of HIV-1 gene …
Selection of TAR RNA-binding chameleon peptides by using a retroviral replication system
B Xie, V Calabro, MA Wainberg, AD Frankel - Journal of virology, 2004 - Am Soc Microbiol
The interaction between the arginine-rich motif (ARM) of the human immunodeficiency virus
(HIV) Tat protein and TAR RNA is essential for Tat activation and viral replication. Two …
(HIV) Tat protein and TAR RNA is essential for Tat activation and viral replication. Two …
Fragments of the HIV-1 Tat protein specifically biand TAR RNA
KM Weeks, C Ampe, SC Schultz, TA Steitz… - Science, 1990 - science.org
Proteolytically produced carboxyl-terminal fragments of the human immunodeficiency virus
type-1 (HIV-1) Tat protein that include a conserved region rich in arginine and lysine bind …
type-1 (HIV-1) Tat protein that include a conserved region rich in arginine and lysine bind …
Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic “hot spots”
The targeting of RNA for the design of novel anti-viral compounds has until now proceeded
largely without incorporating direct input from structure-based design methodology, partly …
largely without incorporating direct input from structure-based design methodology, partly …
Human Immunodeficiency Virus Type 1 Tat and Rev as Potential Targets for Drug Development
S Nekhai, KT Jeang - Antiviral Research: Strategies in Antiviral …, 2009 - Wiley Online Library
This chapter discusses the potential of HIV Tat, Rev, and their cellular cofactors as drug
targets. Tat interacts with numerous transcriptional regulatory factors and presumably by …
targets. Tat interacts with numerous transcriptional regulatory factors and presumably by …