Evidence for a base triple in the free HIV-1 TAR RNA
H Huthoff, F Girard, SS Wijmenga, B Berkhout - Rna, 2004 - rnajournal.cshlp.org
We propose the existence of a novel base triple in the HIV-1 TAR hairpin. This triple is
supported by covariation of loop residue 31 with residue 22, which is part of an unusual …
supported by covariation of loop residue 31 with residue 22, which is part of an unusual …
Altering the context of an RNA bulge switches the binding specificities of two viral Tat proteins
The bovine immunodeficiency virus (BIV) Tat protein binds with high affinity to its TAR RNA
site through a large set of specific RNA− protein contacts whereas human immunodeficiency …
site through a large set of specific RNA− protein contacts whereas human immunodeficiency …
Targeting tat–tar rna interaction for hiv-1 inhibition
The HIV-1 Tat protein interacts with TAR RNA and recruits CDK9/cyclin T1 and other host
factors to induce HIV-1 transcription. Thus, Tat–TAR RNA interaction, which is unique for HIV …
factors to induce HIV-1 transcription. Thus, Tat–TAR RNA interaction, which is unique for HIV …
α‐Helix‐Mimetic Foldamers for Targeting HIV‐1 TAR RNA
An oligopyridylamide‐based foldamer approach has been employed to target HIV TAR RNA‐
TAT assembly as a model system to study RNA‐protein interactions. The oligopyridylamide …
TAT assembly as a model system to study RNA‐protein interactions. The oligopyridylamide …
Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR
A Gatignol, A Buckler-White, BEN Berkhout, KT Jeang - Science, 1991 - science.org
Human immunodeficiency virus type 1 (HIV-1) gene expression is activated by Tat, a virally
encoded protein. Tat trans-activation requires viral (trans-activation—responsive; TAR) RNA …
encoded protein. Tat trans-activation requires viral (trans-activation—responsive; TAR) RNA …
HIV-1 TAR RNA recognition by an unnatural biopolymer
X Wang, I Huq, TM Rana - Journal of the American Chemical …, 1997 - ACS Publications
Small peptides with unnatural backbones that can bind with high affinity to any
predetermined RNA structure would provide useful tools in molecular biology and medicine …
predetermined RNA structure would provide useful tools in molecular biology and medicine …
An Arg/Lys-rich core peptide mimics TRBP binding to the HIV-1 TAR RNA upper-stem/loop
M Erard, DG Barker, F Amalric, KT Jeang… - Journal of molecular …, 1998 - Elsevier
TRBP is a cellular protein that binds to the HIV-1 leader RNA, TAR. Circular dichroism
experiments have shown that a 24 amino acid peptide (TR1), located within a dsRNA …
experiments have shown that a 24 amino acid peptide (TR1), located within a dsRNA …
Creating a ribonuclease T-tat that preferentially recognizes and hydrolyzes HIV-1 TAR RNA in vitro and in vivo
C Dow-Tien, T Yuan-Jhih, L Alan - Nucleic acids research, 2008 - academic.oup.com
A ribonuclease, RNase T-tat, specifically designed to hydrolyze the TAR RNA of HIV-1 virus
has been engineered. The protein was made by domain swapping the TAT peptide at the …
has been engineered. The protein was made by domain swapping the TAT peptide at the …
Inhibition of HIV-1 in CEM cells by a potent TAR decoy.
TAR decoys are short RNA oligonucleotides, corresponding to the HIV TAR sequence,
which inhibit HIV expression and replication by blocking the binding of the HIV regulatory …
which inhibit HIV expression and replication by blocking the binding of the HIV regulatory …
[PDF][PDF] Targeting Tat–TAR RNA Interaction for HIV-1 Inhibition. Viruses 2021, 13, 2004
The HIV-1 Tat protein interacts with TAR RNA and recruits CDK9/cyclin T1 and other host
factors to induce HIV-1 transcription. Thus, Tat–TAR RNA interaction, which is unique for HIV …
factors to induce HIV-1 transcription. Thus, Tat–TAR RNA interaction, which is unique for HIV …