Besides generating novel binding peptides or small molecules to their RNA target,
successful design of chemically modified RNA constructs capable of tighter binding with …

Trans-activation of HIV-1 by the Tat protein is mediated through a cis-acting element (TAR)
in the viral RNA. In order to obtain further insight into the molecular interactions for trans …

Based on a split-and-mix strategy, a library of trimeric Polyamide Amino Acids (PAA)
incorporating four different amino acids (Lys, Ala, Arg, and Phe) has been prepared …

The formation of the Tat-protein/TAR-RNA complex is a crucial step in the regulation of
human immunodeficiency virus (HIV)-gene expression. To obtain full-length viral transcripts …

An arginine-rich peptide from the Jembrana disease virus (JDV) Tat protein is a structural
“chameleon” that binds bovine immunodeficiency virus (BIV) or HIV TAR RNAs in two …

Regulation of HIV gene expression is crucially dependent on binding of the trans-activator
protein, Tat, to the trans-activation response RNA element, TAR, found at the 5 'end of all …

Basic molecular building blocks such as benzene rings, amidines, guanidines, and amino
groups have been combined in a systematic way to generate ligand candidates for HIV-1 …

The Tat protein binds to TAR RNA to stimulate the expression of the human
immunodeficiency virus type 1 (HIV-1) genome. Tat is an 86 amino acid protein that contains …

Abstract The HIV-1 TAR RNA represents a well-known paradigm to study the role of
dynamics and conformational change in RNA function. This regulatory RNA changes …

A series of neomycin dimers have been synthesized using “click chemistry” with varying
functionality and length in the linker region to target the human immunodeficiency virus type …