[引用][C] Inhibitors of the Tat–TAR Interactions
CU Dinesh, TM Rana - Small Molecule DNA and RNA Binders …, 2002 - Wiley Online Library
This chapter contains sections titled: Introduction Mechanism of Transcriptional Activation by
Tat Tat–TAR Interactions RNA as a Small Molecule Drug Target Ligands for TAR RNA TAR …
Tat Tat–TAR Interactions RNA as a Small Molecule Drug Target Ligands for TAR RNA TAR …
Recognition of HIV-1 TAR RNA by Tat protein and Tat-derived peptides
F Aboul-ela, G Varani - Journal of Molecular Structure: THEOCHEM, 1998 - Elsevier
The human immunodeficiency virus (HIV-1) Tat protein stimulates transcriptional elongation
by binding the trans-activation response region (TAR) RNA encoded by all HIV-1 transcripts …
by binding the trans-activation response region (TAR) RNA encoded by all HIV-1 transcripts …
Deciphering structure-activity relationships in a series of Tat/TAR inhibitors
L Pascale, AL González, A Di Giorgio… - Journal of …, 2016 - Taylor & Francis
A series of pentameric “Polyamide Amino Acids”(PAAs) compounds derived from the same
trimeric precursor have been synthesized and investigated as HIV TAR RNA ligands, in the …
trimeric precursor have been synthesized and investigated as HIV TAR RNA ligands, in the …
Strategies to block HIV transcription: focus on small molecule Tat inhibitors
G Mousseau, S Valente - Biology, 2012 - mdpi.com
After entry into the target cell, the human immunodeficiency virus type I (HIV) integrates into
the host genome and becomes a proviral eukaryotic transcriptional unit. Transcriptional …
the host genome and becomes a proviral eukaryotic transcriptional unit. Transcriptional …
The structure of the human immunodeficiency virus type-1 TAR RNA reveals principles of RNA recognition by Tat protein
The human immunodeficiency virus type-1 (HIV-1) Tat protein stimulates transcriptional
elongation. Tat is introduced to the transcription machinery by binding to the transactivation …
elongation. Tat is introduced to the transcription machinery by binding to the transactivation …
In vitro selection of HIV-1 TAR variants by the Tat protein
A Marozzi, R Meneveri, M Giacca, MI Gutierrez… - Journal of …, 1998 - Elsevier
Starting from a pool of 1013 RNA sequences, we isolated a number of TAR RNA variants
after nine rounds of selection by binding to recombinant Tat in vitro (SELEX procedure) …
after nine rounds of selection by binding to recombinant Tat in vitro (SELEX procedure) …
[HTML][HTML] Structure‐based design of a dimeric RNA–peptide complex
DM Campisi, V Calabro, AD Frankel - The EMBO Journal, 2001 - embopress.org
The arginine‐rich RNA‐binding domain of bovine immunodeficiency virus (BIV) Tat adopts a
β‐hairpin conformation upon binding to the major groove of BIV TAR. Based on its NMR …
β‐hairpin conformation upon binding to the major groove of BIV TAR. Based on its NMR …
Inhibition of HIV-1 replication in viral mutants with altered TAR RNA stem structures
MP Rounseville, HC LIN, E Agbottah, RR Shukla… - Virology, 1996 - Elsevier
Human immunodeficiency virus type 1 (HIV-1) Tat-mediatedtrans-activation requires the
structural integrity of TAR RNA and the cooperative interaction of human host cell proteins …
structural integrity of TAR RNA and the cooperative interaction of human host cell proteins …
Oligonucleotide analogue interference with the HIV-1 Tat protein-TAR RNA interaction
A Arzumanov, AP Walsh, X Liu… - … and Nucleic Acids, 2001 - Taylor & Francis
The HIV-1 Tat protein interaction with its RNA recognition sequence TAR is an important
drug target and model system for the development of specific RNA-protein inhibitors. 2′-O …
drug target and model system for the development of specific RNA-protein inhibitors. 2′-O …