Small unnatural peptides that target specific RNA structures have the potential to control
biological processes. RNA− protein interactions are important in many cellular functions …

The ability of RNA structures to adopt diverse yet complex tertiary structures has resulted in
numerous fascinating RNA-protein recognition events. It was recently reported that a close …

Promoter-proximal pausing by RNA polymerase II (Pol II) is a key regulatory step in human
immunodeficiency virus-1 (HIV-1) transcription and thus in the reversal of HIV latency. By …

Tat activates human immunodeficiency type 1 gene expression by binding to TAR RNA. TAR
comprises a partially base paired stem and hexanucleotide loop with a tripyrimidine bulge in …

Aminoglycoside antibiotics were found for the first time to inhibit an HIV-1 Tat-derived
peptide binding to TAR RNA. The IC50 values of neomycin, streptomycin, and gentamicin …

Interactions between viral encoded regulatory proteins and RNA target sequences control
gene expression of Lentiviruses, including human immunodeficiency virus (HIV). Bovine …

The Tat protein of human immunodeficiency virus type 1 (HIV-1) trans-activates viral gene
expression and is obligatory for virus replication. Tat function is mediated through a …

Basic peptides from the carboxy terminus of the HIV-1 Tat protein bind to the stem-loop
region of TAR RNA, spanning a trinucleotide bulge, with high affinity and moderate …

The HIV-1 transactivator protein Tat interacts with the transactivation response element
(TAR) at the three-nucleotide UCU bulge to facilitate the recruitment of transcription …

The main transcriptional regulator of the human immunodeficiency virus, the Tat protein,
recognizes and binds to a small structured RNA element at the 5 'end of every viral mRNA …