Decreased fatty acid oxidation gene expression in pre-Eclampsia according to the onset and presence of intrauterine growth restriction

A Abascal-Saiz, E Fuente-Luelmo, M Haro… - Nutrients, 2023 - mdpi.com
Mitochondrial fatty acid oxidation (FAO) is lower in placentas with pre-eclampsia. The aim of
our study was to compare the placental mRNA expression of FAO enzymes in healthy …

Decreased mitochondrial fatty acid oxidation in placentas from women with preeclampsia

JL Bartha, F Visiedo, A Fernandez-Deudero, F Bugatto… - Placenta, 2012 - Elsevier
Preeclampsia is a leading cause of maternal and fetal morbidity and mortality in high and
low-income countries. The aetiology of preeclampsia is multifactorial and remains obscure …

The regulation of fatty acid oxidation in human preeclampsia

EK Shin, HY Kang, H Yang, EM Jung… - Reproductive …, 2016 - journals.sagepub.com
Preeclampsia (PE) is a pregnancy disorder characterized by high blood pressure, placental
oxidative stress, and proteinuria. In a GeneFishing experiment using human preeclamptic …

Tissue specific expression of human fatty acid oxidation enzyme genes in late pregnancy

JL Bartha, F Bugatto, Á Fernández-Deudero… - Lipids in health and …, 2016 - Springer
Background Abnormal fatty acid oxidation (FAO) is associated with maternal and fetal
complications during pregnancy. The contribution of maternal and fetal tissues to FAO …

The relationship between free fatty acids and mitochondrial oxidative stress damage to trophoblast cell in preeclampsia

L Jiang, J Yan - BMC Pregnancy and Childbirth, 2022 - Springer
Aim To investigate the effects of free fatty acids on mitochondrial oxidative stress and the
pathogenesis of preeclampsia. Methods Human primary trophoblast cells at 6–8 weeks of …

Relationships between concentrations of free fatty acid in serum and oxidative-damage levels in placental mitochondria and preeclampsia

JY Yan, X Xu - Zhonghua Fu Chan Ke Za Zhi, 2012 - europepmc.org
Objective To investigate the relationships between concentrations of free fatty acid (FFA) in
maternal serum and oxidative damage levels in placental mitochondria and preeclampsia …

Association of placental fatty acid desaturase 2 (FADS2) methylation with maternal fatty acid levels in women with preeclampsia

K Dave, L Kaur, D Sundrani, P Sharma… - … and Essential Fatty …, 2022 - Elsevier
Introduction Biosynthesis of long-chain polyunsaturated fatty acids requires sequential
activities of desaturases and elongases for conversion of fatty acid precursors to products …

Correlation of long-chain fatty acid oxidation with oxidative stress and inflammation in pre-eclampsia-like mouse models

X Ding, Z Yang, Y Han, H Yu - Placenta, 2015 - Elsevier
Introduction Pre-eclampsia has been further recognized as a syndrome during pregnancy.
Recent studies have found that long-chain fatty acid oxidation (FAO) disorders may be …

Fatty acid oxidation changes and the correlation with oxidative stress in different preeclampsia-like mouse models

X Ding, Z Yang, Y Han, H Yu - PLoS One, 2014 - journals.plos.org
Background Long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) expression is
decreased in placenta of some cases of preeclampsia (PE) which may result in free fatty …

Placental lipid metabolism in preeclampsia

AA Khaire, SR Thakar, GN Wagh… - Journal of …, 2021 - journals.lww.com
Objectives: The current study examines the placental and maternal lipid profile and
expression of genes involved in placental lipid metabolism in women with preeclampsia …