[HTML][HTML] Membranotropic and biological activities of the membrane fusion peptides from SARS-CoV spike glycoprotein: The importance of the complete internal fusion …
Fusion peptides (FP) are prominent hydrophobic segments of viral fusion proteins that play
critical roles in viral entry. FPs interact with and insert into the host lipid membranes …
critical roles in viral entry. FPs interact with and insert into the host lipid membranes …
Cholesterol and Ceramide Facilitate Membrane Fusion Mediated by the Fusion Peptide of the SARS-CoV-2 Spike Protein
K Niort, J Dancourt, E Boedec, Z Al Amir Dache… - ACS …, 2023 - ACS Publications
SARS-CoV-2 entry into host cells is mediated by the Spike (S) protein of the viral envelope.
The S protein is composed of two subunits: S1 that induces binding to the host cell via its …
The S protein is composed of two subunits: S1 that induces binding to the host cell via its …
Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), represents a global crisis. Key to SARS-CoV-2 therapeutic …
coronavirus 2 (SARS-CoV-2), represents a global crisis. Key to SARS-CoV-2 therapeutic …
Inhibition of viral membrane fusion by peptides and approaches to peptide design
N Düzgüneş, N Fernandez-Fuentes, K Konopka - Pathogens, 2021 - mdpi.com
Fusion of lipid-enveloped viruses with the cellular plasma membrane or the endosome
membrane is mediated by viral envelope proteins that undergo large conformational …
membrane is mediated by viral envelope proteins that undergo large conformational …
[HTML][HTML] In silico design of antiviral peptides targeting the spike protein of SARS-CoV-2
An outbreak caused by 2019 novel coronavirus (2019-nCoV) was first identified in Wuhan
City, Hubei Province, China. The new virus was later named SARS-CoV-2. The virus has …
City, Hubei Province, China. The new virus was later named SARS-CoV-2. The virus has …
SARS-CoV-2 fusion peptide has a greater membrane perturbating effect than SARS-CoV with highly specific dependence on Ca2+
AL Lai, JH Freed - Journal of Molecular Biology, 2021 - Elsevier
Coronaviruses are a major infectious disease threat, and include the zoonotic-origin human
pathogens SARS-CoV-2, SARS-CoV, and MERS-CoV (SARS-2, SARS-1, and MERS). Entry …
pathogens SARS-CoV-2, SARS-CoV, and MERS-CoV (SARS-2, SARS-1, and MERS). Entry …
Structural diversity of the SARS-CoV-2 Omicron spike
Aided by extensive spike protein mutation, the SARS-CoV-2 Omicron variant overtook the
previously dominant Delta variant. Spike conformation plays an essential role in SARS-CoV …
previously dominant Delta variant. Spike conformation plays an essential role in SARS-CoV …
Enhanced receptor binding of SARS-CoV-2 through networks of hydrogen-bonding and hydrophobic interactions
Molecular dynamics and free energy simulations have been carried out to elucidate the
structural origin of differential protein–protein interactions between the common receptor …
structural origin of differential protein–protein interactions between the common receptor …
Transient lipid-bound states of spike protein heptad repeats provide insights into SARS-CoV-2 membrane fusion
Entry of SARS-CoV-2 into a host cell is mediated by spike, a class I viral fusion protein
responsible for merging the viral and host cell membranes. Recent studies have revealed …
responsible for merging the viral and host cell membranes. Recent studies have revealed …
Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry
H Sun, Y Li, P Liu, C Qiao, X Wang, L Wu… - Emerging Microbes & …, 2020 - Taylor & Francis
Dear editor, Emerging and re-emerging pathogens are global challenges for public health
[1]. Since the end of 2019, a cluster of coronavirus disease 2019 (COVID-19) cases have …
[1]. Since the end of 2019, a cluster of coronavirus disease 2019 (COVID-19) cases have …