The recent outbreaks of SARS-CoV-2 pose a global health emergency. The SARS-CoV-2
trimeric spike (S) glycoprotein interacts with the human ACE2 receptor to mediate viral entry …

The development of computational strategies for the quantitative characterization of the
functional mechanisms of SARS-CoV-2 spike proteins is of paramount importance in efforts …

SARS-CoV-2 spike glycoprotein mediates receptor binding and subsequent membrane
fusion. It exists in a range of conformations, including a closed state unable to bind the ACE2 …

The ongoing pandemic of COVID-19, caused by SARS-CoV-2, has substantially increased
the risk to global public health. Multiple vaccines and neutralizing antibodies (nAbs) have …

Pandemic influenza virus and SARS-CoV-2 vaiants have posed major global threats to
public health. Broad-spectrum antivirals blocking viral entry can be an effective strategy for …

It is unclear how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
leads to the strong but ineffective inflammatory response that characterizes severe …

A mechanistic understanding of the SARS-CoV-2 viral replication cycle is essential to
develop new therapies for the COVID-19 global health crisis. In this study, we show that the …

The entry of SARS-CoV-2 into host cells depends on the refolding of the virus-encoded
spike protein from a prefusion conformation, which is metastable after cleavage, to a lower …

The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused devastating impacts …

S-acylation, also known as palmitoylation, is the most widely prevalent form of protein
lipidation, whereby long-chain fatty acids get attached to cysteine residues facing the …