[HTML][HTML] Molecular architecture of the SARS-CoV-2 virus

H Yao, Y Song, Y Chen, N Wu, J Xu, C Sun, J Zhang… - Cell, 2020 - cell.com
SARS-CoV-2 is an enveloped virus responsible for the COVID-19 pandemic. Despite recent
advances in the structural elucidation of SARS-CoV-2 proteins, the detailed architecture of …

Targeting the SARS-CoV-2 spike glycoprotein prefusion conformation: virtual screening and molecular dynamics simulations applied to the identification of potential …

A Romeo, F Iacovelli, M Falconi - Virus research, 2020 - Elsevier
The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
led to a renewed interest in studying the role of the spike S glycoprotein in regulating …

An HR2-mimicking sulfonyl-γ-AApeptide is a potent pan-coronavirus fusion inhibitor with strong blood–brain barrier permeability, long half-life, and promising oral …

S Xue, W Xu, L Wang, X Wang, Q Duan… - ACS Central …, 2023 - ACS Publications
Neutralizing antibodies and fusion inhibitory peptides have the potential required to combat
the global pandemic caused by SARS-CoV-2 and its variants. However, the lack of oral …

Membrane cholesterol modulates oligomeric status and peptide-membrane interaction of severe acute respiratory syndrome coronavirus fusion peptide

G Meher, S Bhattacharjya… - The Journal of Physical …, 2019 - ACS Publications
The N-terminal fusion peptide (residues 770–788) of an S2 glycoprotein of the severe acute
respiratory syndrome coronavirus (SARS-CoV), exposed upon receptor binding, is crucial …

Binding of SARS‐CoV‐2 to Cell Receptors: A Tale of Molecular Evolution

SA Gómez, N Rojas‐Valencia, S Gómez… - …, 2021 - Wiley Online Library
The magnified infectious power of the SARS‐CoV‐2 virus compared to its precursor SARS‐
CoV is intimately linked to an enhanced ability in the mutated virus to find available …

Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor

K Yang, C Wang, AJB Kreutzberger… - Proceedings of the …, 2023 - National Acad Sciences
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
introduced a relatively large number of mutations, including three mutations in the highly …

SARS-CoV-2 fusion-inhibitory lipopeptides maintain high potency against divergent variants of concern including Omicron

Y Zhu, X Dong, N Liu, T Wu, H Chong… - Emerging Microbes & …, 2022 - Taylor & Francis
The emergence of SARS-CoV-2 Omicron and other variants of concern (VOCs) has brought
huge challenges to control the COVID-19 pandemic, calling for urgent development of …

[HTML][HTML] Lipid bilayer degradation induced by SARS-CoV-2 spike protein as revealed by neutron reflectometry

A Luchini, S Micciulla, G Corucci, KC Batchu… - Scientific reports, 2021 - nature.com
SARS-CoV-2 spike proteins are responsible for the membrane fusion event, which allows
the virus to enter the host cell and cause infection. This process starts with the binding of the …

[HTML][HTML] Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets

F Mihalič, C Benz, E Kassa, R Lindqvist… - Nature …, 2023 - nature.com
The virus life cycle depends on host-virus protein-protein interactions, which often involve a
disordered protein region binding to a folded protein domain. Here, we used proteomic …

Repurposing of FDA-approved toremifene to treat COVID-19 by blocking the spike glycoprotein and NSP14 of SARS-CoV-2

WR Martin, F Cheng - Journal of proteome research, 2020 - ACS Publications
The global pandemic of Coronavirus Disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to the death of more than …