Decoding the proteome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for cell-penetrating peptides involved in pathogenesis or applicable as …

S Hemmati, Y Behzadipour, M Haddad - Infection, Genetics and Evolution, 2020 - Elsevier
Synthetic or natural derived cell-penetrating peptides (CPPs) are vastly investigated as tools
for the intracellular delivery of membrane-impermeable molecules. As viruses are …

Detergent modulates the conformational equilibrium of SARS-CoV-2 Spike during cryo-EM structural determination

SB Egri, X Wang, MA Díaz-Salinas, J Luban… - Nature …, 2023 - nature.com
The Spike glycoprotein of SARS-CoV-2 mediates viral entry into the host cell via the
interaction between its receptor binding domain (RBD) and human angiotensin-converting …

Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant

S Xia, JFW Chan, L Wang, F Jiao, KKH Chik, H Chu… - Cell Research, 2022 - nature.com
Dear Editor, Most recently, a new SARS-CoV-2 variant of concern (VOC), Omicron (B. 1.1.
529), was first reported to the World Health Organization (WHO) from South Africa and then …

Structural and molecular perspectives of SARS-CoV-2

S Kumar, SK Saxena - Methods, 2021 - Elsevier
Recent emergence of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
transpired into pandemic coronavirus disease 2019 (COVID-19). SARS-CoV-2 has been …

Structural impact on SARS-CoV-2 spike protein by D614G substitution

J Zhang, Y Cai, T Xiao, J Lu, H Peng, SM Sterling… - Science, 2021 - science.org
Substitution for aspartic acid (D) by glycine (G) at position 614 in the spike (S) protein of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears to facilitate rapid …

Suppression of O-linked glycosylation of the SARS-CoV-2 spike by quaternary structural restraints

CFS Eldrid, JD Allen, ML Newby, M Crispin - Analytical Chemistry, 2021 - ACS Publications
Understanding the glycosylation of the envelope spike (S) protein of SARS-CoV-2 is
important in defining the antigenic surface of this key viral target. However, the underlying …

Revealing the structural plasticity of SARS-CoV-2 nsp7 and nsp8 using structural proteomics

VV Courouble, SK Dey, R Yadav, J Timm… - Journal of the …, 2021 - ACS Publications
Coronavirus (CoV) nonstructural proteins (nsps) assemble to form the replication–
transcription complex (RTC) responsible for viral RNA synthesis. nsp7 and nsp8 are …

Beyond shielding: the roles of glycans in the SARS-CoV-2 spike protein

L Casalino, Z Gaieb, JA Goldsmith, CK Hjorth… - ACS central …, 2020 - ACS Publications
The ongoing COVID-19 pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has resulted in more than 28,000,000 infections and 900,000 …

A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein

B Khatri, I Pramanick, SK Malladi, RS Rajmani… - Nature Chemical …, 2022 - nature.com
Protein tertiary structure mimetics are valuable tools to target large protein–protein
interaction interfaces. Here, we demonstrate a strategy for designing dimeric helix-hairpin …

A SARS-CoV-2 BioID-based virus-host membrane protein interactome and virus peptide compendium: new proteomics resources for COVID-19 research

JR St-Germain, A Astori, P Samavarchi-Tehrani… - BioRxiv, 2020 - biorxiv.org
Key steps of viral replication take place at host cell membranes, but the detection of
membrane-associated protein-protein interactions using standard affinity-based approaches …