Fragile bone is the root cause of osteoporosis. For inherited or acquired reasons, the fragile
bone does not provide sufficient fracture resistance to withstand the physical strains of a …

Osteoporosis is a leading public health problem in our rapidly growing, aging population. It
is characterized by reduced bone mass and microarchitectural deterioration of bone tissue …

Osteoporosis is a complex multifactorial disorder of the skeleton. Genetic factors are
important in determining peak bone mass and structure, as well as the predisposition to …

Purpose: As the population ages, there is an increased risk of fracture and morbidity
diseases associated with aging, such as age-related osteoporosis and other bone diseases …

Osteoporosis is a complex multifactorial condition of the musculoskeletal system.
Osteoporosis and osteoporotic vertebral fracture (OVF) are associated with high medical …

Epigenetics describes mechanisms which control gene expression and cellular processes
without changing the DNA sequence. The main mechanisms in epigenetics are DNA …

BACKGROUND Osteoporosis is a condition characterized by low BMD and micro‐
architectural deterioration leading to increased fracture risk. Osteoporosis affects up to 40 …

Osteoporosis is an age-related progressive bone disease. Recent advances in epigenetics,
cell biology, osteoimmunology, and genetic epidemiology have unraveled new mechanisms …

Bone tissue is a continuous remodeling system, which is regulated by complex processes of
genetic and epigenetic control. Both the first and the second system in osteoporosis, as a …

Genomic technologies have evolved rapidly contributing to the understanding of diseases.
Genome-wide association studies (GWAS) and whole-exome sequencing have aided the …