Genetics of osteoporosis from genome-wide association studies: advances and challenges

JB Richards, HF Zheng, TD Spector - Nature Reviews Genetics, 2012 - nature.com
Osteoporosis is among the most common and costly diseases and is increasing in
prevalence owing to the ageing of our global population. Clinically defined largely through …

Molecular mechanisms of osteoporosis

Z Li, KG Yang - Frontiers in Endocrinology, 2023 - frontiersin.org
Osteoporosis is a metabolic bone disorder that threatens holistic well-being and economic
stability worldwide due to its high prevalence in the elderly. Osteoporosis is associated with …

The molecular and epigenetic regulation of osteoblast and osteoclast differentiation and the implications in osteoporosis

B Yu - 2014 - escholarship.org
The human skeleton undergoes continuous bone remodeling, a process relying on
orchestrated balance between the actions of osteoblasts and osteoclasts. Complex …

[PDF][PDF] Genetic research in osteoporosis: Where are we? Where should we go next?

RR Recker - Journal of Musculoskeletal and Neuronal Interactions, 2004 - ismni.org
Fractures resulting from low bone mass and excessive skeletal fragility (osteoporosis) are
common worldwide both in males and females, particularly in later years of life. Both …

Molecular mechanisms and emerging therapeutics for osteoporosis

JY Noh, Y Yang, H Jung - International journal of molecular sciences, 2020 - mdpi.com
Osteoporosis is the most common chronic metabolic bone disease. It has been estimated
that more than 10 million people in the United States and 200 million men and women …

Epigenetic therapies of osteoporosis

F de Nigris, C Ruosi, G Colella, C Napoli - Bone, 2021 - Elsevier
The study of epigenetics reaches its 50th anniversary, however, its clinical application is
gradually coming into the clinical setting. Osteoporosis is one of the major and widely …

Osteoblast biology

JB Lian, GS Stein - Osteoporosis, 2001 - Elsevier
Publisher Summary This chapter presents the cell biology of osteoblasts within the content
of current understanding of the regulatory controls operative in promoting osteoblast …

The roles of epigenetics regulation in bone metabolism and osteoporosis

F Xu, W Li, X Yang, L Na, L Chen, G Liu - Frontiers in cell and …, 2021 - frontiersin.org
Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …

Novel insights into the complex architecture of osteoporosis molecular genetics

FA Saad - Annals of the New York Academy of Sciences, 2020 - Wiley Online Library
Osteoporosis is a prevalent osteodegenerative disease and silent killer linked to a decrease
in bone mass and decline of bone microarchitecture, due to impaired bone matrix …

Epigenetics and bone remodeling

A Husain, MA Jeffries - Current osteoporosis reports, 2017 - Springer
Abstract Purpose of Review Bone remodeling is a diverse field of study with many direct
clinical applications; past studies have implicated epigenetic alterations as key factors of …