Genetics of osteoporosis from genome-wide association studies: advances and challenges
Osteoporosis is among the most common and costly diseases and is increasing in
prevalence owing to the ageing of our global population. Clinically defined largely through …
prevalence owing to the ageing of our global population. Clinically defined largely through …
Molecular mechanisms of osteoporosis
Z Li, KG Yang - Frontiers in Endocrinology, 2023 - frontiersin.org
Osteoporosis is a metabolic bone disorder that threatens holistic well-being and economic
stability worldwide due to its high prevalence in the elderly. Osteoporosis is associated with …
stability worldwide due to its high prevalence in the elderly. Osteoporosis is associated with …
The molecular and epigenetic regulation of osteoblast and osteoclast differentiation and the implications in osteoporosis
B Yu - 2014 - escholarship.org
The human skeleton undergoes continuous bone remodeling, a process relying on
orchestrated balance between the actions of osteoblasts and osteoclasts. Complex …
orchestrated balance between the actions of osteoblasts and osteoclasts. Complex …
[PDF][PDF] Genetic research in osteoporosis: Where are we? Where should we go next?
RR Recker - Journal of Musculoskeletal and Neuronal Interactions, 2004 - ismni.org
Fractures resulting from low bone mass and excessive skeletal fragility (osteoporosis) are
common worldwide both in males and females, particularly in later years of life. Both …
common worldwide both in males and females, particularly in later years of life. Both …
Molecular mechanisms and emerging therapeutics for osteoporosis
JY Noh, Y Yang, H Jung - International journal of molecular sciences, 2020 - mdpi.com
Osteoporosis is the most common chronic metabolic bone disease. It has been estimated
that more than 10 million people in the United States and 200 million men and women …
that more than 10 million people in the United States and 200 million men and women …
Epigenetic therapies of osteoporosis
The study of epigenetics reaches its 50th anniversary, however, its clinical application is
gradually coming into the clinical setting. Osteoporosis is one of the major and widely …
gradually coming into the clinical setting. Osteoporosis is one of the major and widely …
Osteoblast biology
JB Lian, GS Stein - Osteoporosis, 2001 - Elsevier
Publisher Summary This chapter presents the cell biology of osteoblasts within the content
of current understanding of the regulatory controls operative in promoting osteoblast …
of current understanding of the regulatory controls operative in promoting osteoblast …
The roles of epigenetics regulation in bone metabolism and osteoporosis
F Xu, W Li, X Yang, L Na, L Chen, G Liu - Frontiers in cell and …, 2021 - frontiersin.org
Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …
Novel insights into the complex architecture of osteoporosis molecular genetics
FA Saad - Annals of the New York Academy of Sciences, 2020 - Wiley Online Library
Osteoporosis is a prevalent osteodegenerative disease and silent killer linked to a decrease
in bone mass and decline of bone microarchitecture, due to impaired bone matrix …
in bone mass and decline of bone microarchitecture, due to impaired bone matrix …
Epigenetics and bone remodeling
A Husain, MA Jeffries - Current osteoporosis reports, 2017 - Springer
Abstract Purpose of Review Bone remodeling is a diverse field of study with many direct
clinical applications; past studies have implicated epigenetic alterations as key factors of …
clinical applications; past studies have implicated epigenetic alterations as key factors of …