Mitochondria, the powerhouse of the neural cells in the brain, are also the seat of certain
essential gene signaling pathways that control neuronal functions. Deterioration of …

Parkinson's disease is a progressive neurodegenerative disease in the elderly, and no cure
or disease-modifying therapies exist. Several lines of evidence suggest that mitochondrial …

Parkinson's disease is the second most common neurodegenerative disorder characterized
by persistent loss of dopaminergic neurons in the SN and clinically associated with …

Mitochondrial abnormalities have been identified as a central mechanism in multiple
neurodegenerative diseases and, therefore, the mitochondria have been explored as a …

In recent years, multiple disciplines have focused on mitochondrial biology and contributed
to understanding its relevance towards adult-onset neurodegenerative disorders. These are …

Aging is a progressive loss of physiological function that increases risk of disease and
death. Among the many factors that contribute to human aging, mitochondrial dysfunction …

Mitochondria are critical for homeostasis and metabolism in all cellular eukaryotes. Brain
mitochondria are the primary source of fuel that supports many brain functions, including …

Maintaining the functional integrity of mitochondria is pivotal for cellular survival. It appears
that neuronal homeostasis depends on high-fidelity mitochondria, in particular …

A case in support of mitochondrial dysfunction in Parkinson's disease (PD) has received
support from animal modeling studies as well as studies performed on biopsied material …

Many lines of evidence have indicated the therapeutic potential of rescuing mitochondrial
integrity by targeting specific mitochondrial quality control pathways in neurodegenerative …