The chromogranin A1‐373 fragment reveals how a single change in the protein sequence exerts strong cardioregulatory effects by engaging neuropilin‐1
Abstract Aim Chromogranin A (CgA), a 439‐residue long protein, is an important
cardiovascular regulator and a precursor of various bioactive fragments. Under …
cardiovascular regulator and a precursor of various bioactive fragments. Under …
The homologous rat chromogranin A1‐64 (rCGA1‐64) modulates myocardial and coronary function in rat heart to counteract adrenergic stimulation indirectly via …
Chromogranin A (CGA), produced by human and rat myocardium, generates several
biologically active peptides processed at specific proteolytic cleavage sites. A highly …
biologically active peptides processed at specific proteolytic cleavage sites. A highly …
Full-length human chromogranin-A cardioactivity: myocardial, coronary, and stimulus-induced processing evidence in normotensive and hypertensive male rat hearts
Plasma chromogranin-A (CgA) concentrations correlate with severe cardiovascular
diseases, whereas CgA-derived vasostatin-I and catestatin elicit cardiosuppression via an …
diseases, whereas CgA-derived vasostatin-I and catestatin elicit cardiosuppression via an …
Chromogranin-A: a multifaceted cardiovascular role in health and disease
Chromogranin A (CgA), a major component of the chromaffin granules, is co-stored and co-
released with catecholamines. It is also expressed in extra-adrenal sites, including the heart …
released with catecholamines. It is also expressed in extra-adrenal sites, including the heart …
Recombinant N–terminal fragments of chromogranin–a modulate cardiac function of the Langendorff–perfused rat heart
In this study we tested the hypothesis that vasostatins could act as myocardial modulators in
the mammalian heart. Using the Langendorff–perfused rat heart, the cardiac effects of the …
the mammalian heart. Using the Langendorff–perfused rat heart, the cardiac effects of the …
Myocardial production of chromogranin A in human heart: a new regulatory peptide of cardiac function
Abstract Aims High chromogranin-A (CgA) levels were observed in patients with heart failure
but its source remained uncertain. We evaluated whether CgA is produced by myocardium …
but its source remained uncertain. We evaluated whether CgA is produced by myocardium …
Cytoskeleton mediates negative inotropism and lusitropism of chromogranin A-derived peptides (human vasostatin1-78 and rat CgA1-64) in the rat heart
Cytoskeleton scaffold in cardiac myocytes provides structural support and
compartmentalization of intracellular components. It is implicated in cardiac pathologies …
compartmentalization of intracellular components. It is implicated in cardiac pathologies …
Human recombinant chromogranin A-derived vasostatin-1 mimics preconditioning via an adenosine/nitric oxide signaling mechanism
S Cappello, T Angelone, B Tota… - American Journal …, 2007 - journals.physiology.org
The acidic protein chromogranin A (CgA) is the precursor of several regulatory peptides
generated by specific proteolytic processes. Human recombinant CgA NH2-terminal …
generated by specific proteolytic processes. Human recombinant CgA NH2-terminal …
Chromogranin A: a novel factor acting at the cross road between the neuroendocrine and the cardiovascular systems
G Di Comite, A Morganti - Journal of hypertension, 2011 - journals.lww.com
Chromogranin A (CHGA) is a secretory protein stored in and released from neurons and
cells of the diffuse neuroendocrine system. Cells of the adrenal medulla and adrenergic …
cells of the diffuse neuroendocrine system. Cells of the adrenal medulla and adrenergic …
The interplay between chromogranin A-derived peptides and cardiac natriuretic peptides in cardioprotection against catecholamine-evoked stress
Chromogranin A (CgA) is the major soluble protein co-stored and co-released with
catecholamines (CAs) from secretory vesicles in the adrenal medulla chromaffin cells …
catecholamines (CAs) from secretory vesicles in the adrenal medulla chromaffin cells …