Cardiac electrical activity in a genomically “humanized” chromogranin a monogenic mouse model with hyperadrenergic hypertension
The prohormone chromogranin A (CHGA) is ubiquitously found in vesicles of adrenal
chromaffin cells and adrenergic neurons, and it is processed to the hypotensive hormone …
chromaffin cells and adrenergic neurons, and it is processed to the hypotensive hormone …
Modulation of the coronary tone in the expanding scenario of Chromogranin-A and its derived peptides
The cardiac function critically depends on an adequate myocardial oxygenation and on a
correct coronary blood flow. Endothelial, hormonal and extravascular factors work together …
correct coronary blood flow. Endothelial, hormonal and extravascular factors work together …
Chromogranin A in heart failure. A novel neurohumoral factor and a predictor for mortality
C Ceconi, R Ferrari, T Bachetti, C Opasich… - European heart …, 2002 - academic.oup.com
Background In chronic heart failure, several hormonal systems are activated with diagnostic
and prognostic implications. We tested the hypotheses that serum Chromogranin-A (CgA) …
and prognostic implications. We tested the hypotheses that serum Chromogranin-A (CgA) …
Endothelium dependent cardiovascular effects of the chromogranin A-derived peptides vasostatin-1 and catestatin
S Fornero, E Bassino, MP Gallo… - Current medicinal …, 2012 - ingentaconnect.com
The involvement of Chromogranin A (CgA) in the cardiovascular function regulation is
attributed to its function as a prohormone. Several studies indicated that CgA-derived …
attributed to its function as a prohormone. Several studies indicated that CgA-derived …
Chromogranin A as a biomarker in cardiovascular disease
JP Goetze, U Alehagen, A Flyvbjerg… - Biomarkers in …, 2014 - Taylor & Francis
Chromogranin A is known as an important marker of neuroendocrine tumors. In
cardiovascular medicine, however, chromogranin A measurement has only recently gained …
cardiovascular medicine, however, chromogranin A measurement has only recently gained …
A novel catestatin-induced antiadrenergic mechanism triggered by the endothelial PI3K–eNOS pathway in the myocardium
E Bassino, S Fornero, MP Gallo… - Cardiovascular …, 2011 - academic.oup.com
Aims Catestatin (CST) is a chromogranin A (CgA)-derived peptide (hCgA352–372) with
three identified human variants (G364S/P370L/R374Q-CST) that show differential potencies …
three identified human variants (G364S/P370L/R374Q-CST) that show differential potencies …
Effects of chromogranin A deficiency and excess in vivo: biphasic blood pressure and catecholamine responses
SM Vaingankar, Y Li, N Biswas, J Gayen… - Journal of …, 2010 - journals.lww.com
Objective The phenotype of the chromogranin A (Chga) null (knockout) mouse is
hypertensive. However, hypertensive humans and spontaneously hypertensive rats display …
hypertensive. However, hypertensive humans and spontaneously hypertensive rats display …
Phosphodiesterase type-2 and NO-dependent S-nitrosylation mediate the cardioinhibition of the antihypertensive catestatin
T Angelone, AM Quintieri, T Pasqua… - American Journal …, 2012 - journals.physiology.org
The chromogranin A (CHGA)-derived peptide catestatin (CST: hCHGA352–372) is a
noncompetitive catecholamine-release inhibitor that exerts vasodilator, antihypertensive …
noncompetitive catecholamine-release inhibitor that exerts vasodilator, antihypertensive …
[HTML][HTML] Catestatin exerts direct protective effects on rat cardiomyocytes undergoing ischemia/reperfusion by stimulating PI3K-Akt-GSK3β pathway and preserving …
Catestatin (Cst) is a 21-amino acid peptide deriving from Chromogranin A. Cst exerts an
overall protective effect against an excessive sympathetic stimulation of cardiovascular …
overall protective effect against an excessive sympathetic stimulation of cardiovascular …
[HTML][HTML] Muscle injury, impaired muscle function and insulin resistance in Chromogranin A-knockout mice
K Tang, T Pasqua, A Biswas, S Mahata… - The Journal of …, 2017 - ncbi.nlm.nih.gov
Chromogranin A (CgA) is widely expressed in endocrine and neuroendocrine tissues as
well as in the central nervous system. We observed CgA expression (mRNA and protein) in …
well as in the central nervous system. We observed CgA expression (mRNA and protein) in …