Pluripotent stem cells have broad applications in regenerative medicine and offer ideal
models for understanding the biological process of embryonic development and specific …

There is increasing evidence that long noncoding RNAs (lncRNAs) are among the main
regulatory factors of stem cell maintenance and differentiation. They act through various …

Highlights•Cis-and trans-acting lncRNAs are involved in stem cell pluripotency and
reprogramming.•lncRNA-mediated cis regulation of nearby transcription is a prevalent …

Maintenance of the pluripotent state or differentiation of the pluripotent state into any germ
layer depends on the factors that orchestrate expression of thousands of genes through …

LncRNAs have recently emerged as new and fundamental transcriptional and post-
transcriptional regulators acting at multiple levels of gene expression. Indeed, lncRNAs …

Divergent lncRNAs that are transcribed in the opposite direction to nearby protein-coding
genes comprise a significant proportion (∼ 20%) of total lncRNAs in mammalian genomes …

Stem cells are distinctive cells that have self-renewal potential and unique ability to
differentiate into multiple functional cells. Stem cell is a frontier field of life science research …

Noncoding RNAs are critical regulatory factors in essentially all forms of life. Stem cells
occupy a special position in cell biology and Biomedicine, and emerging results show that …

The most part of our genome encodes for RNA transcripts are never translated into proteins.
These include families of RNA molecules with a regulatory function, which can be arbitrarily …

Human chromosomes are pervasively transcribed, but systematic understanding of coding
and long noncoding RNA (lncRNA) genome function in cell differentiation is lacking. Using …