Epigenetic modifications of the nuclear genome, including DNA methylation, histone
modifications and non-coding RNA post-transcriptional regulation, are increasingly being …

Over the last two decades, the mutation of mitochondrial DNA (mtDNA) has emerged as a
major cause of inherited human disease. The disorders present clinically in at least 1 in 10 …

Recent expansion of our knowledge on epigenetic changes strongly suggests that not only
nuclear DNA (nDNA), but also mitochondrial DNA (mtDNA) may be subjected to epigenetic …

DNA methylation is a common epigenetic modification of the mammalian genome.
Conflicting data regarding the possible presence of methylated cytosines within …

Maintenance of the mitochondrial genome is essential for proper cellular function. For this
purpose, mitochondrial DNA (mtDNA) needs to be faithfully replicated, transcribed …

Aim: In the present study, we investigated whether global DNA methylation levels are
affected by mitochondrial DNA (mtDNA) variants, which are known to modulate …

Methylation of nuclear genes encoding mitochondrial proteins participates in the regulation
of mitochondria function. The existence of cytosine methylation in the mitochondrial genome …

Mitochondrial dysfunction plays critical roles in cancer development and related therapeutic
response; however, exact molecular mechanisms remain unclear. Recently, alongside the …

Epigenetics provides an important layer of information on top of the DNA sequence and is
essential for establishing gene expression profiles. Extensive studies have shown that …

Despite decades of research, mitochondrial epigenetics remains a controversial notion.
Recent findings, however, indicate that dysfunctional mitochondrial DNA (mtDNA) …