Mitogen-activated protein kinase (MAPK) pathways are prominently involved in the onset
and progression of cancer. In particular, aberrant activation of MAPK pathways is mostly the …

Extracellular signal-regulated kinase (ERK) is a part of the mitogen-activated protein kinase
(MAPK) signaling pathway which allows the transduction of various cellular signals to final …

Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction
pathways that regulate all aspects of life and are frequently altered in disease. Here, we …

Mitogen-activated protein kinase (MAPK) cascades are key signaling pathways involved in
the regulation of normal cell proliferation, survival and differentiation. Aberrant regulation of …

The mitogen-activated protein kinases (MAPK) pathway, often known as the RAS-RAF-MEK-
ERK signal cascade, functions to transmit upstream signals to its downstream effectors to …

Introduction: The RAS/RAF/MAP kinase–ERK kinase (MEK)/extracellular-signal-regulated
kinase (ERK)(MAPK) and the PI3K/AKT/mammalian target of rapamycin (mTOR)(PI3K) …

The mitogen-activated protein kinases (MAPKs) have been under careful investigation for a
long period, and this signaling pathway is one of the most studied. MAPKs regulate cell …

ERK1 and ERK2 (ERKs), two extracellular regulated kinases (ERK1/2), are evolutionary-
conserved and ubiquitous serine-threonine kinases involved in regulating cell signalling in …

The importance of mitogen-activated protein kinases (MAPK) in human pathology is
underlined by the relevance of abnormalities of MAPK-related signaling pathways to a …

Mitogen-activated protein kinases (MAPKs) regulate diverse cellular processes including
proliferation, cell survival, differentiation, and apoptosis. While conventional MAPK …