Animal models of hidden hearing loss: Does auditory-nerve-fiber loss cause real-world listening difficulties?
KS Henry - Molecular and Cellular Neuroscience, 2022 - Elsevier
Afferent innervation of the cochlea by the auditory nerve declines during aging and
potentially after sound overexposure, producing the common pathology known as cochlear …
potentially after sound overexposure, producing the common pathology known as cochlear …
Cochlear Synaptopathy and Noise‐Induced Hidden Hearing Loss
Recent studies on animal models have shown that noise exposure that does not lead to
permanent threshold shift (PTS) can cause considerable damage around the synapses …
permanent threshold shift (PTS) can cause considerable damage around the synapses …
Divergent auditory nerve encoding deficits between two common etiologies of sensorineural hearing loss
Speech intelligibility can vary dramatically between individuals with similar clinically defined
severity of hearing loss based on the audiogram. These perceptual differences, despite …
severity of hearing loss based on the audiogram. These perceptual differences, despite …
[HTML][HTML] Hidden hearing loss impacts the neural representation of speech in background noise
JJM Monaghan, JA Garcia-Lazaro, D McAlpine… - Current Biology, 2020 - cell.com
Many individuals with seemingly normal hearing abilities struggle to understand speech in
noisy backgrounds. To understand why this might be the case, we investigated the neural …
noisy backgrounds. To understand why this might be the case, we investigated the neural …
[HTML][HTML] Cochlear synaptopathy changes sound-evoked activity without changing spontaneous discharge in the mouse inferior colliculus
LA Shaheen, MC Liberman - Frontiers in systems neuroscience, 2018 - frontiersin.org
Tinnitus and hyperacusis are life-disrupting perceptual abnormalities that are often
preceded by acoustic overexposure. Animal models of overexposure have suggested a link …
preceded by acoustic overexposure. Animal models of overexposure have suggested a link …
Normal tone-in-noise sensitivity in trained budgerigars despite substantial auditory-nerve injury: no evidence of hidden hearing loss
KS Henry, KS Abrams - Journal of Neuroscience, 2021 - Soc Neuroscience
Loss of auditory-nerve (AN) afferent cochlear innervation is a prevalent human condition that
does not affect audiometric thresholds and therefore remains largely undetectable with …
does not affect audiometric thresholds and therefore remains largely undetectable with …
[HTML][HTML] Noise-induced hearing loss in gerbil: round window assays of synapse loss
Previous work in animals with recovered hearing thresholds but permanent inner hair cell
synapse loss after noise have suggested initial vulnerability of low spontaneous rate (SR) …
synapse loss after noise have suggested initial vulnerability of low spontaneous rate (SR) …
Perceptual consequences of “hidden” hearing loss
CJ Plack, D Barker, G Prendergast - Trends in hearing, 2014 - journals.sagepub.com
Dramatic results from recent animal experiments show that noise exposure can cause a
selective loss of high-threshold auditory nerve fibers without affecting absolute sensitivity …
selective loss of high-threshold auditory nerve fibers without affecting absolute sensitivity …
Non-invasive assays of cochlear synaptopathy–candidates and considerations
Studies in multiple species, including in post-mortem human tissue, have shown that normal
aging and/or acoustic overexposure can lead to a significant loss of afferent synapses …
aging and/or acoustic overexposure can lead to a significant loss of afferent synapses …
Hot Topics—Hidden hearing loss: Permanent cochlear-nerve degeneration after temporary noise-induced threshold shift
MC Liberman, SG Kujawa - The Journal of the Acoustical Society of …, 2014 - pubs.aip.org
The classic view of sensorineural hearing loss (SNHL) is that the “primary” targets are hair
cells, and that cochlear-nerve loss is “secondary” to hair cell degeneration. Our work in …
cells, and that cochlear-nerve loss is “secondary” to hair cell degeneration. Our work in …