Nerve growth factor (NGF), an essential peptide for sensory neurons, seems to have
opposite effects when administered peripherally or directly to the central nervous system …

Animal models of neuropathic pain involving incomplete nerve injury result in causalgia-like
symptoms, including thermal hyperalgesia and mechanical allodynia. Although current …

To reveal roles of neurotrophic factors in plastic changes of the primary afferent neurons
following nerve injury, we investigated expression of glial cell line-derived neurotrophic …

When a silicone tube is implanted in transected rat sciatic nerve, there is plasma
accumulation and formation of a fibrin cable followed by proliferation and migration of neural …

Peripheral nerve injury can promote neuropathic pain. The basis of the 'central
sensitization'that underlies this often intractable condition was investigated using 14–20‐day …

It is without dispute that the treatment of neuropathic pain is an area of largely unmet
medical need. Available analgesics, such as morphine, either have minimal effects in …

Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are two major
members of the neurotrophin family. Using immunohistochemistry and in situ hybridization …

Glial fibrillary acidic protein (GFAP) is a specific astrocytic marker in the central nervous
system. Few studies on the effects of glial cell line-derived neurotrophic factor (GDNF) …

Neurotrophic factors, such as nerve growth factor and brain-derived neurotrophic factor, are
members of the structurally related neurotrophin family that play important roles in pain …

Neuropathic pain is driven by abnormal peripheral and central processing, and treatments
are insufficiently effective. Antibodies against nerve growth factor (anti-NGF) have been …