Inhibition of amiodarone‐induced lung fibrosis but not alveolitis by angiotensin system antagonists
Earlier work in this laboratory showed that amiodarone induces apoptosis in alveolar
epithelial cells by a mechanism inhibitable by angiotensin system antagonists. A variety of …
epithelial cells by a mechanism inhibitable by angiotensin system antagonists. A variety of …
[HTML][HTML] Amiodarone induces apoptosis of human and rat alveolar epithelial cells in vitro
R Bargout, A Jankov, E Dincer… - … of Physiology-Lung …, 2000 - journals.physiology.org
The antiarrhythmic amiodarone (AM) and its metabolite desethylamiodarone (Des) are
known to cause AM-induced pulmonary toxicity, but the mechanisms underlying this …
known to cause AM-induced pulmonary toxicity, but the mechanisms underlying this …
Amiodarone-induced pulmonary fibrosis in hamsters
JO Cantor, M Osman, JM Cerreta… - Experimental lung …, 1984 - Taylor & Francis
Amiodarone, a cardiac antiarrhythmic agent, has been associated with the development of
interstitial pulmonary fibrosis in patients receiving prolonged therapy with the drug. To …
interstitial pulmonary fibrosis in patients receiving prolonged therapy with the drug. To …
Amiodarone induces angiotensinogen gene expression in lung alveolar epithelial cells through activation protein‐1
BD Uhal, H Zhang, A Abdul‐Hafez… - Basic & clinical …, 2007 - Wiley Online Library
Previous work from this laboratory has shown that amiodarone induces alveolar epithelial
cell apoptosis that was abrogated by antagonists of angiotensin II. In this study, amiodarone …
cell apoptosis that was abrogated by antagonists of angiotensin II. In this study, amiodarone …
Amiodarone-induced pulmonary toxicity in Fischer rats: release of tumor necrosis factor alpha and transforming growth factor beta by pulmonary alveolar …
PG Reinhart, CG Gairola - Journal of toxicology and environmental …, 1997 - Taylor & Francis
Amiodarone is an antiarrhythmic drug with numerous side effects, the most serious being the
development of pulmonary toxicity. We have previously reported that a single intratra cheal …
development of pulmonary toxicity. We have previously reported that a single intratra cheal …
Pulmonary responses to amiodarone in hamsters: Comparison of intratracheal and oral administrations
TL Blake, MJ Reasor - Toxicology and applied pharmacology, 1995 - Elsevier
Amiodarone (AD) has been shown to produce a transient pulmonary fibrosis in hamsters
after intratracheal (it) instillation. The goal of this study was to examine bronchoalveolar …
after intratracheal (it) instillation. The goal of this study was to examine bronchoalveolar …
Amiodarone causes acute oxidant lung injury in ventilated and perfused rabbit lungs
TP Kennedy, GB Gordon, A Paky… - Journal of …, 1988 - journals.lww.com
Amiodarone (ADR), a new antiarrhythmic drug for life-threatening cardiac arrhythmias,
causes pneumonitis or lung fibrosis in a sizeable minority of patients. The cause of lung …
causes pneumonitis or lung fibrosis in a sizeable minority of patients. The cause of lung …
Amiodarone-induced pulmonary toxicity in the rat
BD Wilson, AJ Jaworski, ME Donner, ML Lippmann - Lung, 1989 - Springer
A rat model of amiodarone-induced pulmonary toxicity is described. The rats were fed, by
gavage, 175 mg/kg/day of amiodarone hydrochloride suspended in methyl cellulose …
gavage, 175 mg/kg/day of amiodarone hydrochloride suspended in methyl cellulose …
Amiodarone-induced pulmonary inflammation
BD Wilson, CE Clarkson, ML Lippmann - Am Rev Respir Dis, 1991 - atsjournals.org
Toinvestigate the hypotheses that amiodarone-induced pulmonary inflammation may be
related to direct drug toxicity, groups of 10or more Wistar rats were fed amiodarone by …
related to direct drug toxicity, groups of 10or more Wistar rats were fed amiodarone by …
Attenuation of amiodarone-induced lung fibrosis and phospholipidosis in hamsters by taurine and/or niacin treatment.
Q Wang, MA Hollinger, SN Giri - Journal of Pharmacology and Experimental …, 1992 - ASPET
Therapeutic use of amiodarone (AD), an effective antiarrhythmic drug, is associated with
serious pulmonary toxicity (eg, fibrosis and phospholipidosis). In the present study, we …
serious pulmonary toxicity (eg, fibrosis and phospholipidosis). In the present study, we …