Earlier work in this laboratory showed that amiodarone induces apoptosis in alveolar
epithelial cells by a mechanism inhibitable by angiotensin system antagonists. A variety of …

The antiarrhythmic amiodarone (AM) and its metabolite desethylamiodarone (Des) are
known to cause AM-induced pulmonary toxicity, but the mechanisms underlying this …

Amiodarone, a cardiac antiarrhythmic agent, has been associated with the development of
interstitial pulmonary fibrosis in patients receiving prolonged therapy with the drug. To …

Previous work from this laboratory has shown that amiodarone induces alveolar epithelial
cell apoptosis that was abrogated by antagonists of angiotensin II. In this study, amiodarone …

Amiodarone is an antiarrhythmic drug with numerous side effects, the most serious being the
development of pulmonary toxicity. We have previously reported that a single intratra cheal …

Amiodarone (AD) has been shown to produce a transient pulmonary fibrosis in hamsters
after intratracheal (it) instillation. The goal of this study was to examine bronchoalveolar …

Amiodarone (ADR), a new antiarrhythmic drug for life-threatening cardiac arrhythmias,
causes pneumonitis or lung fibrosis in a sizeable minority of patients. The cause of lung …

A rat model of amiodarone-induced pulmonary toxicity is described. The rats were fed, by
gavage, 175 mg/kg/day of amiodarone hydrochloride suspended in methyl cellulose …

Toinvestigate the hypotheses that amiodarone-induced pulmonary inflammation may be
related to direct drug toxicity, groups of 10or more Wistar rats were fed amiodarone by …

Therapeutic use of amiodarone (AD), an effective antiarrhythmic drug, is associated with
serious pulmonary toxicity (eg, fibrosis and phospholipidosis). In the present study, we …