Immune system dysfunction causes dysregulation of immune homeostasis, which in turn
leads to autoimmune diseases. Regulatory T cells (Tregs) are a specialized T cell …

The autoimmune reaction against the beta cells of the pancreatic islets in type 1 diabetes
mellitus (T1DM) patients is active in prediabetes and during the development of the clinical …

Type 1 diabetes mellitus (T1DM) is a T cell-mediated autoimmune disease resulting in islet β
cell destruction, hypoinsulinemia, and severely altered glucose homeostasis. T1DM has …

Background: The critical role for regulatory T cells (Treg) in suppressing autoimmune
pathology is now well recognised. However, the extent to which defects in regulation can be …

Genetic and cellular studies of type 1 diabetes in patients and in the nonobese diabetic
mouse model of type 1 diabetes point to an imbalance between effector T cells and …

T-regulatory cells (Tregs) play a fundamental role in the creation and maintenance of
peripheral tolerance. Deficits in the numbers and/or function of Tregs may be an underlying …

Introduction Accumulating evidence suggests that defective regulation is an essential
underlying cause of autoimmunity. The development of type 1 diabetes in the NOD mouse …

Regulatory T-cells (Tregs) play important role in regulation of immune responses to self-
antigens. Alterations in frequency and function of Tregs have been reported in Type 1 …

Type 1 diabetes mellitus (T1DM) is a T cell-mediated autoimmune disease characterized by
the destruction of pancreatic β cells. Numerous studies have demonstrated the key role of …

Tregs play an important role in controlling immune responses, particularly autoimmunity. In
NOD mouse model, an excellent model for autoimmune diabetes, transfer of Tregs was …