Frequent loss of heterozygosity (LOH) on the short arm of human chromosome 3 (3p) region
has been found in pancreatic cancer (PC), which suggests the likely presence of tumor …

Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA. The reactivation
of telomerase activity by aberrant upregulation/expression of its catalytic subunit hTERT is a …

Telomerase is a ribonucleoprotein ribonucleic enzyme that elongates telomere repeat
sequences at the ends of chromosomes and contributes to cellular immortalization. The …

Telomerase activation is crucial for cells that tend to be immortalized. Increased telomerase
activity is correlated with upregulation of telomerase reverse transcriptase (TERT) …

Telomerase, a ribonucleoprotein enzyme that maintains telomere length, is crucial for
cellular immortalization and cancer progression. Telomerase activity is attributed primarily to …

Telomerase reverse transcriptase (TERT) promotes immortalization by protecting telomeres
in cancer cells. Mutation of the TERT promoter is one of the most common genetic …

Telomerase is crucial for human carcinogenesis. The limiting component of telomerase
activity is telomerase reverse transcriptase (hTERT), undetectable in differentiated somatic …

Based on the sites of frequent allelic loss in hepatocellular carcinoma, five normal human
chromosomes (2, 4, 5, 10 and 16) were transferred individually into a telomerase-positive …

Narrowing the search for the critical hTERT repressor sequence (s) has identified three
regions on chromosome 3p (3p12-p21. 1, 3p21. 2 and 3p21. 3-p22). However, the precise …

Duplication of chromosomal arm 20q occurs in prostate, cervical, colon, gastric, bladder,
melanoma, pancreas and breast cancer, suggesting that 20q amplification may play a …