Background and Aims Thioesterase superfamily member 2 (Them2) is highly expressed in
liver and oxidative tissues, where it hydrolyzes long‐chain fatty acyl‐CoA esters to free fatty …

Thioesterase superfamily member 1 (Them1) is an acyl-CoA thioesterase that is highly
expressed in brown adipose tissue, where it functions to suppress energy expenditure …

In nonalcoholic fatty liver disease (NAFLD), triglycerides accumulate within the liver because
the rates of fatty acid accrual by uptake from plasma and de novo synthesis exceed …

Mammalian acyl-CoA thioesterases (Acots) catalyze the hydrolysis of fatty acyl-CoAs to form
free fatty acids plus CoA, but their metabolic functions remain undefined. Thioesterase …

Members of the acyl-CoA thioesterase (Acot) gene family catalyze the hydrolysis of fatty acyl-
CoAs, but their biological functions remain unknown. Thioesterase superfamily member 2 …

Mammalian cells express acyl‐CoA thioesterases (Acots), which regulate intracellular fatty
acid metabolism. Them1, also known as Acot11, suppresses energy expenditure by limiting …

Abstract Objective Thioesterase superfamily member 1 (Them1) is a long chain acyl-CoA
thioesterase comprising two N-terminal HotDog fold enzymatic domains linked to a C …

Thioesterase superfamily member 2 (Them2) is a mitochondrion-associated long-chain fatty
acyl coenzyme A (CoA) thioesterase that is highly expressed in the liver and oxidative …

Hepatic insulin resistance in the setting of steatosis is attributable at least in part to the
accumulation of bioactive lipids that suppress insulin signaling. The mitochondria …

In brown adipose tissue, thermogenesis is suppressed by thioesterase superfamily member
1 (Them1), a long chain fatty acyl-CoA thioesterase. Them1 is highly upregulated by cold …