In brown adipose tissue, thermogenesis is suppressed by thioesterase superfamily member
1 (Them1), a long chain fatty acyl-CoA thioesterase. Them1 is highly upregulated by cold …

Objective Non-shivering thermogenesis in brown adipose tissue (BAT) plays a central role in
energy homeostasis. Thioesterase superfamily member 1 (Them1), a BAT-enriched long …

Members of the acyl-CoA thioesterase (Acot) gene family hydrolyze fatty acyl-CoAs, but their
biological functions remain incompletely understood. Thioesterase superfamily member 2 …

Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in
developed countries. NAFLD describes a wide range of liver pathologies from simple …

The incorporation of excess saturated free fatty acids (SFAs) into membrane phospholipids
within the ER promotes ER stress, insulin resistance, and hepatic gluconeogenesis …

Them2 (thioesterase superfamily member 2) is a 140-amino-acid protein of unknown
biological function that comprises a single hotdog fold thioesterase domain. On the basis of …

Nonalcoholic fatty liver disease (NAFLD) is a common liver disease that ranges from simple
steatosis to nonalcoholic steatohepatitis (NASH). So far, the underlying mechanism remains …

Nonalcoholic steatohepatitis (NASH) is a common metabolic disorder that is a major
contributor to health care expenditures worldwide. Enoyl coenzyme A hydratase 1 (ECH1) is …

Human carboxylesterase 2 (CES2) has triacylglycerol hydrolase (TGH) activities and plays
an important role in lipolysis. In this study, we aim to determine the role of human CES2 in …

Inter-organ crosstalk has gained increasing attention in recent times; however, the
underlying mechanisms remain unclear. In this study, we elucidate an endocrine pathway …