[PDF][PDF] Sirtuin 2 prevents liver steatosis and metabolic disorders by deacetylation of hepatocyte nuclear factor 4α
H Ren, F Hu, D Wang, X Kang, X Feng, L Zhang… - …, 2021 - Wiley Online Library
Background and Aims Sirtuin 2 (SIRT2), an NAD+‐dependent deacetylase, is involved in
various cellular processes regulating metabolic homeostasis and inflammatory responses; …
various cellular processes regulating metabolic homeostasis and inflammatory responses; …
[HTML][HTML] Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine …
G Chalhoub, A Jamnik, L Pajed, S Kolleritsch… - Molecular …, 2023 - Elsevier
Objective Hepatic triacylglycerol accumulation and insulin resistance are key features of
NAFLD. However, NAFLD development and progression are rather triggered by the aberrant …
NAFLD. However, NAFLD development and progression are rather triggered by the aberrant …
[HTML][HTML] Regulation of mitochondrial trifunctional protein modulates nonalcoholic fatty liver disease in mice
Mitochondrial trifunctional protein (MTP) plays a critical role in the oxidation of long-chain
fatty acids. We previously reported that aging mice (> 9 months old) heterozygous for an …
fatty acids. We previously reported that aging mice (> 9 months old) heterozygous for an …
[HTML][HTML] Discovery of a peripheral 5HT2A antagonist as a clinical candidate for metabolic dysfunction-associated steatohepatitis
HS Pagire, SH Pagire, B Jeong, WI Choi, CJ Oh… - Nature …, 2024 - nature.com
Abstract Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is currently the
leading cause of chronic liver disease worldwide. Metabolic Dysfunction-Associated …
leading cause of chronic liver disease worldwide. Metabolic Dysfunction-Associated …
Liver-specific expression of carboxylesterase 1g/esterase-x reduces hepatic steatosis, counteracts dyslipidemia and improves insulin signaling
W Bahitham, R Watts, R Nelson, J Lian… - Biochimica et Biophysica …, 2016 - Elsevier
Ces1g/Es-x deficiency in mice results in weight gain, insulin resistance, fatty liver and
hyperlipidemia through upregulation of de novo lipogenesis and oversecretion of …
hyperlipidemia through upregulation of de novo lipogenesis and oversecretion of …
[HTML][HTML] Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis …
Spermidine is a natural polyamine that has health benefits and extends life span in several
species. Deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH) are key …
species. Deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH) are key …
[HTML][HTML] Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway
HJ Kim, Y Joe, SK Kim, SU Park, J Park, Y Chen… - Free Radical Biology …, 2017 - Elsevier
Nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic
syndrome, has emerged as one of the most common causes of chronic liver disease in …
syndrome, has emerged as one of the most common causes of chronic liver disease in …
[HTML][HTML] Dietary choline alleviates high-fat diet-induced hepatic lipid dysregulation via UPRmt modulated by SIRT3-mediated mtHSP70 deacetylation
YF Song, H Zheng, Z Luo, C Hogstrand, ZY Bai… - International Journal of …, 2022 - mdpi.com
The mitochondrial unfolded protein response (UPRmt) is known as a conservative
mechanism in response to mitochondrial dysfunction. Thus, based on UPRmt, this study was …
mechanism in response to mitochondrial dysfunction. Thus, based on UPRmt, this study was …
[HTML][HTML] The protective effect of selenoprotein M on non-alcoholic fatty liver disease: the role of the AMPKα1–MFN2 pathway and Parkin mitophagy
J Cai, J Huang, J Yang, X Chen, H Zhang… - Cellular and Molecular …, 2022 - Springer
Non-alcoholic fatty liver disease (NAFLD) is related to a dysregulation of mitophagy, a
process that is not fully understood. Parkin-related mitophagy can sustain mitochondrial …
process that is not fully understood. Parkin-related mitophagy can sustain mitochondrial …
Hepatic knockdown of endothelin type A receptor (ETAR) ameliorates hepatic insulin resistance and hyperglycemia through suppressing p66Shc-mediated …
L Feng, S Wang, F Chen, C Zhang… - Diabetes, Metabolic …, 2021 - Taylor & Francis
Background Emerging evidence from animal studies and clinical trials indicates that
systemic inhibition of endothelin1 (ET1) signaling by endothelin receptor antagonists …
systemic inhibition of endothelin1 (ET1) signaling by endothelin receptor antagonists …