[HTML][HTML] Aquaporin 5 facilitates corneal epithelial wound healing and nerve regeneration by reactivating Akt signaling pathway

Y Liu, G Di, Y Wang, D Chong, X Cao… - The American journal of …, 2021 - Elsevier
Aquaporins (AQPs) are a highly conserved group of membrane proteins that play critical
roles in water and small solute transport across epithelial and endothelial barriers. The aim …

Aquaporin 5 promotes corneal wound healing

SS Kumari, M Varadaraj, AG Menon… - Experimental eye …, 2018 - Elsevier
Aquaporins (AQPs), ordinarily regarded as water channels, have recently been shown to
participate in other cellular functions such as cell-to-cell adhesion, cell migration, cell …

[HTML][HTML] Effect of down-regulation of aquaporins in human corneal endothelial and epithelial cell lines

J Shankardas, RV Patil, JK Vishwanatha - Molecular Vision, 2010 - ncbi.nlm.nih.gov
Purpose The purpose of this study was to determine the effects of down-regulation of
Aquaporin 1 (AQP1) and Aquaporin 5 (AQP5) on cell proliferation and migration in human …

Aquaporin-1-facilitated keratocyte migration in cell culture and in vivo corneal wound healing models

J Ruiz-Ederra, AS Verkman - Experimental eye research, 2009 - Elsevier
Aquaporin-1 (AQP1) water channels are expressed in corneal keratocytes, which become
activated and migrate following corneal wounding. The purpose of this study was to …

Loss of aquaporin 5 contributes to the corneal epithelial pathogenesis via Wnt/β‐catenin pathway

Y Wang, G Di, K Zhang, Y Bai, X Cao… - The FASEB …, 2023 - Wiley Online Library
AQP5 plays a crucial role in maintaining corneal transparency and the barrier function of the
cornea. Here, we found that in the corneas of Aqp5−/− mice at older than 6 months, loss of …

Role of aquaporins in corneal healing post chemical injury

ME Bhend, D Kempuraj, NR Sinha, S Gupta… - Experimental eye …, 2023 - Elsevier
Aquaporins (AQPs) are transmembrane water channel proteins that regulate the movement
of water through the plasma membrane in various tissues including cornea. The cornea is …

[HTML][HTML] Aquaporin-3-dependent cell migration and proliferation during corneal re-epithelialization

MH Levin, AS Verkman - Investigative ophthalmology & visual …, 2006 - tvst.arvojournals.org
purpose. To determine a role for the water-and glycerol-transporting protein aquaporin-3
(AQP3) in mammalian corneal epithelium, where it is expressed but has no known function …

Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing

M Hara-Chikuma, AS Verkman - Journal of Molecular Medicine, 2008 - Springer
Healing of skin wounds is a multi-step process involving the migration and proliferation of
basal keratinocytes in epidermis, which strongly express the water/glycerol-transporting …

Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling

JR Thiagarajah, AS Verkman - Journal of Biological Chemistry, 2002 - ASBMB
Two aquaporin (AQP)-type water channels are expressed in mammalian cornea, AQP1 in
endothelial cells and AQP5 in epithelial cells. To test whether these aquaporins are involved …

[HTML][HTML] Spatial expression of aquaporin 5 in mammalian cornea and lens, and regulation of its localization by phosphokinase A

SS Kumari, M Varadaraj, VS Yerramilli… - Molecular …, 2012 - ncbi.nlm.nih.gov
Purpose Aquaporins (AQPs) play a significant role in the movement of water across the
plasma membrane. In the eye, the cornea and lens are avascular with unique …