A clinical trial of frozen platelets: rationale, protocol and pilot analysis plan

DC Marks, L Johnson, MC Reade - ISBT Science Series, 2018 - Wiley Online Library
Introduction Platelets have a short shelf life and may be discarded due to expiry. Smaller
Australian hospitals often cannot justify keeping platelet units on‐site. Cryopreserved …

CLIP (cryopreserved vs. liquid platelets for surgical bleeding): Protocol for a randomised controlled trial

A Royse, MC Reade, L Johnson… - Heart, Lung and …, 2015 - heartlungcirc.org
Methods: CLIP is a 90-patient, 4-hospital pilot blinded randomised controlled effectiveness
trial of cryopreserved platelets in comparison to apheresis platelets. Outcomes that will be …

Cryopreserved platelets compared with liquid-stored platelets for the treatment of surgical bleeding: protocol for two multicentre randomised controlled blinded non …

MC Reade, DC Marks, B Howe, S McGuinness… - BMJ open, 2022 - bmjopen.bmj.com
Introduction Cryopreservation at− 80° C in dimethylsulphoxide extends platelet shelf-life
from 7 days to 2 years. Only limited comparative trial data supports the safety and …

[HTML][HTML] Protocol: Cryopreserved platelets compared with liquid-stored platelets for the treatment of surgical bleeding: protocol for two multicentre randomised …

MC Reade, DC Marks, B Howe, S McGuinness… - BMJ Open, 2022 - ncbi.nlm.nih.gov
Introduction Cryopreservation at− 80 C in dimethylsulphoxide extends platelet shelf-life from
7 days to 2 years. Only limited comparative trial data supports the safety and effectiveness of …

A pilot randomized clinical trial of cryopreserved versus liquid‐stored platelet transfusion for bleeding in cardiac surgery: the cryopreserved versus liquid platelet‐New …

S McGuinness, R Charlewood, E Gilder… - Vox …, 2022 - Wiley Online Library
Abstract Background and Objectives Platelets for transfusion have a shelf‐life of 7 days,
limiting availability and leading to wastage. Cryopreservation at− 80° C extends shelf‐life to …

A randomized, controlled pilot clinical trial of cryopreserved platelets for perioperative surgical bleeding: the CLIP‐I trial (Editorial, p. 2759)

MC Reade, DC Marks, R Bellomo, R Deans… - …, 2019 - Wiley Online Library
BACKGROUND Cryopreservation extends platelet (PLT) shelf life from 5 to 7 days to 2 to 4
years. However, only 73 patients have been transfused cryopreserved PLTs in published …

[PDF][PDF] Vox Sanguinis International Forum on platelet cryopreservation: Summary.

CS Cohn, LJ Dumont, M Lozano, DC Marks… - Vox …, 2017 - academia.edu
The demand for platelets continues to rise, outstripping supply worldwide. In higher-income
countries, cancer patients remain platelet transfusion dependent for extended periods …

Frozen platelets for rural Australia: the CLIP trial

MC Reade, DC Marks, L Johnson… - … and Intensive Care, 2013 - search.proquest.com
Commenting on our review of frozen blood products1 in the previous issue of Anaesthesia
and Intensive Care, Dr Rowe from Armidale in country NSW eloquently highlights the clinical …

[HTML][HTML] Design of the randomized controlled trial comparing dimethyl sulfoxide cryopreserved platelets to liquid stored platelets in patients undergoing …

G Whitman, R Kramer, K Tanaka, J Holcomb… - JTCVS open, 2023 - Elsevier
Objective Dimethylsulfoxide-cryopreserved platelets are being evaluated for treatment of
acute hemorrhage in patients with thrombocytopenia or platelet dysfunction when liquid …

The use of frozen platelets for the treatment of bleeding

DJB Kleinveld, NP Juffermans, F Noorman - Annual Update in Intensive …, 2020 - Springer
Frozen platelets have been used for the treatment of bleeding patients in military and
austere settings. In addition to the advantage of a prolonged shelf life, following thawing …