Abstract Background Interleukin-23 (IL-23) is required for T helper 17 (Th17) cell responses
and IL-17 production in ischemic stroke. We previously showed that the IL-23/IL-17 axis …

Abstract Interleukin-23/interleukin-23 receptor (IL-23/IL-23R) has been implicated in many
inflammatory diseases. Previous research mainly focused on its ability to induce IL-17 …

Acute ischemic stroke is followed by a complex interplay between the brain and the immune
system in which ischemia-reperfusion leads to a detrimental inflammatory response that …

Ischemic stroke causes brain injury with activation of an inflammatory response that can
contribute to clinical impairment. As a novel cytokine of the interleukin-1 (IL-1) family, IL-33 …

Ischemia–reperfusion frequently occurs in ischemic cerebral vascular disease, during which
the inflammatory signaling plays essential roles. The aim of this study was to discover the …

Background Lymphocytes have dichotomous functions in ischemic stroke. Regulatory T cells
are protective, while IL-17A from innate lymphocytes promotes the infarct growth. With recent …

As a prototypical proinflammatory cytokine, interleukin-1 (IL-1) exacerbates the early post-
stroke inflammation, whereas its neutralization is protective. To further investigate the …

Background Microglia/macrophages are activated after cerebral ischemic stroke and can
contribute to either brain injury or recovery by polarizing microglia/macrophage into …

Stroke causes brain injury with neuroinflammation which exacerbates the neuronal damage.
Recent studies show that anti-inflammatory cytokine interleukin-19 (IL-19) plays a critical …

Abstract Background: Interleukin (IL)-17A was reported to be involved in the development of
post-ischemic stroke inflammatory response and functional recovery. However, the IL-17A …