Activation of pro-inflammatory microglia is an important mechanism of the cerebral ischemia–
reperfusion (I/R)-induced neuronal injury and dysfunction. Mesenchymal stem cells (MSCs) …

In recent years, studies have shown that the secretome of bone marrow mesenchymal
stromal cells (BMSCs) contains many growth factors, cytokines, and antioxidants, which may …

Transplantation of bone marrow stromal cells (BMSCs) is a promising therapy for ischemic
stroke, but the poor oxygen environment in brain lesions limits the efficacy of cell-based …

Umbilical cord‐derived mesenchymal stem cells (UC‐MSCs) engraftment is a potential
therapy for cerebral ischemic stroke. However, the harsh microenvironment induced by …

Induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) hold great promise
as a cell source for transplantation into injured tissues to alleviate inflammation. However …

Background Pyroptosis mediated by NLRP3 inflammasome plays a critical role in the
pathogenesis of cerebral ischemia-reperfusion (I/R) injury. Mounting evidences have …

Mesenchymal stem cells (MSCs), which are regarded as promising candidates for cell
replacement therapies, are able to regulate immune responses after traumatic brain injury …

Inflammatory responses play a major role in the pathophysiology of cerebral ischemia.
Mesenchymal stem cell-derived exosomes (MSC-exos) have important anti-inflammatory …

Bone marrow-derived mesenchymal stromal cells (BM-MSCs) represent a promising tool for
stem cell-based therapies. However, the majority of MSCs fail to reach the injury site and …

Microglia play a key role in the immune response and inflammatory reaction that occurs in
response to ischemic stroke. Activated microglia promote neuronal damage or protection in …