The locus coeruleus is connected to the dorsal hippocampus via strong fiber projections. It
becomes activated after arousal and novelty, whereupon noradrenaline is released in the …

Memory is essential in defining our identity by guiding behavior based on past experiences.
However, aging leads to declining memory, disrupting older adult's lives. Memories are …

Catecholamine neurons of the locus coeruleus (LC) in the dorsal pontine tegmentum
innervate the entire neuroaxis, with signaling actions implicated in the regulation of …

Noradrenaline, essential for the modulation of memory, is released in various parts of the
brain from nerve terminals controlled by the locus coeruleus (LoC). Noradrenaline release …

Abstract Changes in synaptic strength are believed to underlie learning and memory. We
explore the idea that norepinephrine is an essential modulator of memory through its ability …

Synaptic plasticity comprises a cellular mechanism through which the hippocampus most
likely enables memory formation. Neuromodulation, related to arousal, is a key aspect in …

Adaptation to the ever-changing world is critical for survival, and our brains are particularly
tuned to remember events that differ from previous experiences. Novel experiences induce …

The noradrenergic system, driven by locus coeruleus (LC) activation, plays a key role in the
regulating and directing of changes in hippocampal synaptic efficacy. The LC releases …

The central noradrenergic (NA) system is critical for the maintenance of attention, behavioral
flexibility, spatial navigation, and learning and memory, those cognitive functions lost first in …

Spatial memory formation is enabled through synaptic information processing, in the form of
persistent strengthening and weakening of synapses, within the hippocampus. It is …