The study of DNA methylation has been a rapidly expanding field since its dawn in the
1960s. DNA methylation is an epigenetic modification that plays a crucial role in guiding the …

Highlights•DNA methylation is an important epigenetic mechanism regulating gene
expression.•DNA methyltransferases add repressing or activating methyl “marks” to …

The rapid advances in high‐throughput sequencing technologies have made it more evident
that epigenetic modifications orchestrate a plethora of complex biological processes. During …

Epigenome regulation is a critical mechanism that governs cell identity, lineage specification
and developmental cell fates. With the advent of low-input and single-cell technologies as …

DNA methylation is a well-studied epigenetic modification essential for efficient cellular
differentiation. Aberrant DNA methylation patterns are a characteristic feature of cancer …

DNA methylation provides a major epigenetic code (besides histone modification) of the
lineage-and developmentspecific genes (such as regulators of differentiation in the …

Aberrant DNA methylation is a characteristic feature of cancers including blood
malignancies. Mutations in the DNA methylation regulators DNMT3A, TET1/2, and IDH1/2 …

Acute myeloid leukemia (AML) is a heterogeneous disease that is characterized by distinct
cytogenetic or genetic abnormalities. Recent discoveries in cancer epigenetics …

DNA methyltransferases (DNMTs) are the key enzymes for genome methylation, which plays
an important role in epigenetically regulated gene expression and repression. Mouse …

In recent years, an explosion of interest for genome methylation in hematopoietic stem cells
(HSCs) differentiation and transplantation has been observed. The differentiation and timely …